6 Acute and Chronic (Late Occurring) Adverse Events, Adverse Events That Disappear (Bendectin), and Diethylstilbesterol Adverse events (AEs) seen shortly after starting or stopping drugs are common and relatively easy…
11 Drug Interactions Analyzing AEs and ascribing the causality to a particular drug can be quite difficult. This difficulty, however, is magnified when the patient also takes additional drugs. This…
3 Spontaneous Postmarketing Adverse Events Their pivotal and irreplaceable role in providing safety information when a wider population is exposed to a new product. Before a drug comes to…
4 The Theory of Drug Safety (Pharmacovigilance) Why a company needs a drug safety group and how it is constituted. The mission of a drug safety group within a pharmaceutical…
10 Children, Elderly, and Other Special (Vulnerable) Groups Background Similar to the testing of new drugs in pregnant women, the testing of drugs in special (“vulnerable”) groups poses issues. Special…
1 The Theory and Definitions of Drug Safety (Pharmacovigilance) What is an adverse event (AE)? A serious AE? An adverse drug reaction (ADR)? A suspected adverse drug reaction (SADR)? A…
Chemical name Common name Class Formula Structure Izopropylmethylphosphonofluoridate Sarin Nerve agent C4H10FO2P Pinacolylmethylphosphonofluoridate Soman Nerve agent C7H16FO2P Cyclohexylmethylphosphonofluoridate Cyclosarin Nerve agent C7H14FO2P Ethyl N,N′-dimethylphosphoroamidocyanidate Tabun Nerve agent C5H11N2O2P O-ethyl, S-2-diisopropylaminoethyl…
Compound CAS number Molecular formula Chemical structure Synonyms Bis-(2-chloroethyl) sulfide 505-60-2 C4-H8-Cl2-S HD, agent HD, mustard gas, yperite, LOST, Sulfur mustard 1,2-Bis-(2-chloroethylthio)-ethane 3563-36-8 C6-H12-Cl2-S2 Q, agent Q, sesquimustard, 1,8-dichloro-3,6-dithiaoctane Bis-(2-chloroethylthioethyl)-ether…
Fig. 9.1 Mild eyelid erythema and conjunctival congestion in acute keratopathy with mild SM exposure A dose of 100–200 mg/m3/min can lead to moderate complaints involving eyelids, conjunctiva and cornea….
Fig. 7.1 Flowchart of the cellular events in acute injury following sulfur mustard exposure. (Red arrow: inhibitory pathway, Dotted line: under study or possible pathway, Boxes with “lock” symbol; Steps…
