(1) Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel KeywordsTissue oxygen balanceEnergy demandEnergy supplyATP consumptionOxygen gradient 2.1 Tissue Energy Metabolism The functional capacity of any tissue is related to…
(1) Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel KeywordsMitochondrial functionNADH fluorescenceIn vivo monitoringOxygen balanceMultiparametric monitoring 1.1 The Mitochondrion The understanding of mitochondrial function has been a challenge for…
Fig. 7.1 The mechanism underlying NO-repressed autophagy. NO inhibits JNK1 phosphorylation by S-nitrosylation. Decrease of phospho-Bcl-2 and increase of Bcl-2-Beclin1 interaction disrupt Vps34-Beclin1 association. NO also inhibits IKKb phosphorylation by S-nitrosylation….
Group A415 A476 Control 24 h 0.044 ± 0.001 0.042 ± 0.004 ART 24 h 0.145 ± 0.002* 0.110 ± 0.003** ART 48 h 0.033 ± 0.001* 0.123 ± 0.002** ART 96 h 0.049 ± 0.002* 0.131 ± 0.002** ART artemisinin. The singular asterisk (*) represents statistically significant difference from…
Metabolites Pathways and genes Up/downregulation folds CR ART H2O2 Glucose Glycolysis Acs2 −17.28 −2.63 −3.02 Adh6 −6.18 −1.54 −3.06 Ald3 −1.49 −1.83 2.13 Eno1 −1.75 −1.38 −2.26 Pdc6 −4.88 −2.16…
Fig. 2.1 The isoprenoid biosynthesis pathway-based opening/closing carbon flux strategies aiming at ART overproduction in A. annua L. ABA abscisic acid; DMAPP dimethylallyl diphosphate; DXP deoxyxylulose 5-phosphate; DXR DXP reductoisomerase; DXS…
Fig. 4.1 Induction of NO production in B. licheniformis upon acclimatization to oxidative stress and suppression of oxidative stress-inducible NO. ART artemisinin; l–NMMA NG-monomethyl-l-arginine monoacetate; NO nitric oxide. Double asterisks (**)…
Fig. 1.1 The multifaceted beneficial effects exerted by ART through specifically targeting a variety of hemoproteins. ART artemisinin; bNOS bacterial nitric oxide synthase; COX cytochrome c oxidase; CR calorie restriction; NO…
Fig. 5.1 Dynamic monitoring of NO production and comparative analysis of relationship between NO and SpO2 in BIA, CIA and BIA-CIA mice. a Time course detection of serum NO levels in…
Chapter 11 The nervous system Who could have foretold, from the structure of the brain, that wine could derange its functions? Hippocrates (460–375 BC) The neurological history The neurological history…
