Evasion strategy Mechanism Impaired tumor antigen presentation • Downregulation of tumor antigens or antigen-processing machinery (e.g., lack of LMP and TAP proteins) [8] • Downregulation of MHC genes [9] Impaired trafficking of…
Fig. 3.1 Microvascular proliferation: microvessels in red (factor VIII) with some dividing endothelial cells in blue (Ki67). Tumor cells (to the left) show high degree of proliferation (Ki67-positive nuclei) In…
Fig. 1.1 Schematic diagram of tissue architecture with regard to the spatial distribution of cellular and extracellular components In other words, in order to expand in size beyond the diffusion…
Fig. 6.1 The tumor microenvironment. Here we show the variety of host-derived stromal cells that are involved in mediating tumor progression. Tumor cells secrete factors that remodel the ECM and…
14 Special Senses Eye and Ear A beautiful eye makes silence eloquent, a kind eye makes contradiction an assent, an enraged eye makes beauty deformed. This little member gives life…
8 Female Reproductive System A woman’s health is her capital. —Harriet Beecher Stowe Chapter Outline Functions of the Female Reproductive System Specialists/Specialties Anatomy and Physiology Pathology Case Study: Olivia Carter…
3 Musculoskeletal System Chapter Outline Functions of the Musculoskeletal System Specialties/Specialists Anatomy and Physiology Axial Skeleton Appendicular Skeleton Case Study: Dylan Koldmann Pathology Case Study: Jean Herold Diagnostic Procedures Therapeutic…
10 Cardiovascular System Chapter Outline Functions of the Cardiovascular System Specialists/Specialties Anatomy and Physiology Case Study: William Woodward Pathology Case Study: Helen Podrasky Diagnostic Procedures Therapeutic Interventions Pharmacology Abbreviations Chapter…
11 Respiratory System Roses are red, Violets are blue, Without your lungs, Your blood would be too. —Susan Ott Chapter Outline Functions of the Respiratory System Specialists/Specialties Anatomy and Physiology…
9 Blood, Lymphatic, and Immune Systems The family you come from isn’t as important as the family you are going to have. —Ring Lardner Chapter Outline Functions of the Blood,…
