Fig. 12.1 Mechanisms of platelet activation. Under normal, physiological conditions, platelets rapidly form a clot upon contact with a site of vascular damage (a). Damage to the endothelium leads to…
, Yaping Hua1, 2, Karl-Henning Kalland1, 2 , Xisong Ke1, 2, Jan Roger Olsen1, 2, Anne Margrete Øyan1, 2 and Yi Qu1, 2 (1) Department of Clinical Science, University of Bergen, Bergen, Norway (2) Department of Microbiology, Haukeland University…
Fig. 11.1 Schematic overview of human diseases associated with the presence of TLS Ectopic Lymphoid Tissue in Autoimmunity and Infectious Diseases In chronic inflammatory diseases, TLS arise at sites of…
Fig. 20.1 Shown are H/E stainings of astrocytomas , WHO grade II–IV as indicated. Grade II astrocytoma displays a slight hypercellularity and moderate cellular pleomorphism. Grade III, or anaplastic astrocytoma,…
Characteristic NRP1 NRP2 Chromosome location 10p11.22 (human) 2q33.3 (human) Molecular weight 130–140 kDa 130–140 kDa Receptor isoforms NRP1, NRP1Δ16 NRP2a17, NRP2a22 NRP2b0, NRP2b5 Soluble forms s11NRP1, s12NRP1, sIIINRP1, sIVNRP1, s10Nrp1…
First author Publication year Country No. of UC patients SIRa Reference Stewenius 1995 Sweden 471 2.1 PMID:7636371 Wandall 2000 Denmark 801 1.7 PMID:10766327 Palli 2000 Italy 689 1.8 PMID:10982757 Jess…
Fig. 9.1 TAM-regulated suppression of inflammatory response in sentinel cells of the innate immune system. Activation of TLR results in the secretion of pro-inflammatory cytokines, which are in positive feed-forward…
Fig. 18.1 Examples of MEArray platforms While these array platforms create caricatures of in vivo microenvironments, they enable researchers to functionally define molecular components that maintain adult and embryonic stem…
Fig. 5.1 Schematic illustration of binding specificities of the five PDGF isoforms and the structural organization of the PDGF receptors PDGF-BB, and PDGF-AA dimers composed of the longer splice variant,…
Fig. 7.1 Arachidonic acid metabolism via cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP450) enzymes. Lipids highlighted include PGE2, LTB4, LTC4, LTD4, LTE4, 11,12-EET, and 14,15-EET for their diverse roles…
