Fig. 12.1 Proposed model for AFSC-mediated tissue repair. Implanted undifferentiated AFSCs evoke a strong pro-inflammatory and pro-angiogenic response, which accounts for the rapid vascularization of the implantation site. Circulating progenitors…
© Springer Science+Business Media New York 2014Anthony Atala and Sean V. Murphy (eds.)Perinatal Stem Cells10.1007/978-1-4939-1118-9_31 31. Towards Clinical Applications of Umbilical Cord Derived Mesenchymal Stem Cells Rouzbeh R. Taghizadeh1 , Paul W. Holzer2, Teresa Marino3, Kyle J. Cetrulo1 , Curtis L. CetruloSr.4 and Curtis L. CetruloJr.5 (1) AuxoCell…
Disease NCT ID Source Dose (/kg) Route Age Follow-up Type of study Location Cerebral Palsy 01072370 Autologous (MNC) 1 × 107 iv 2–12 years old 1 year Phase I/II (placebo, double blinded)…
Indication Phase Institution Enrollment Clinical trials indicator Autism Phase II Sutter Health 30 NCT01638819 Cerebral palsy Phase I/II Georgia Health Sciences University 40 NCT01072370 Cerebral palsy Phase II Duke University…
Fig. 19.1 Human amnion epithelial cells (hAECs) promote tissue repair via the modulation of host immune cells. Through the secretion of lipoxins and other mediators, hAECs polarize M1 macrophages to…
Fig. 13.1 Placenta structure and placenta-derived cells. (a) Illustration of the structure of placenta. (b) Mechanical separation of the fetal membrane and depiction of the different layers of amnion and…
Developmental stage Genes Extracellular matrix proteins References Interzone formation GDF5 (TGFß-superfamily), Sox9, WNT9a, TGFß, BMP2, BMP4, BMP7 Versican, Collagen I, fibronectin [23, 37, 111–114] Cavitation Sox5, Sox6, Sox9, CD44, BMP2,…
Fig. 1.1 Regenerative strategies for cardiac repair. To provide cardiac repair following ischemic injury such as myocardial infarct (MI), three different aspects should be addressed, that is (1) the modulation…
Fig. 5.1 Proven features of amniotic fluid stem cells (AFSCs) supporting a role in fetal cell microchimerism Fetal cell microchimerism is also represented by the presence of fetal DNA in…
Fig. 6.1 Human lung development Development provides the first context where AFSC-based therapies could prove useful. Many genetic and developmental deficiencies, such as pulmonary hypoplasia, could potentially be addressed in…
