Fig. 2.1 Mechanisms of amyloid formation and toxicity. Intrinsic instability, increased concentration, mutations, proteolytic cleavage or a combination thereof can favour the conversion of the amyloidogenic precursor into its misfolded…
Fig. 4.1 Kidney and liver ALECT2 amyloidosis. Eosinophilic amyloid deposits in the kidney with glomerular, interstitial, and vascular involvement (a, H&E) stain with Congo red (b). Congo red stain viewed…
Fibril protein Precursor protein Systemic and/or localized Acquired or hereditary Target organs AL Immunoglobulin light chain S, L A, He All organs except CNS (Local AL amyloidosis may occur) AH…
CHAPTER 12 Approach to Various Skin Lesions John L. Pfenninger This chapter provides guidelines for the diagnosis and treatment of common skin lesions. Table 12-1 can be used as a…
CHAPTER 192 Joint and Soft Tissue Aspiration and Injection (Arthrocentesis) Thad J. Barkdull, Francis G. O’Connor, John M. McShane Joint and soft tissue aspiration and injection are both clinically rewarding…
CHAPTER 225 Emergency Department, Hospitalist, and Office Ultrasonography (Clinical Ultrasonography) Grant C. Fowler For many reasons—including improvements in image quality, portability, and affordability, high-quality research about applications, and more widely…
CHAPTER 106 Office Treatment of Hemorrhoids George G. Zainea, John L. Pfenninger Hemorrhoidal disease occurs in approximately 50% to 80% of the U.S. population. Although this disease is rarely fatal,…
CHAPTER 187 Cast Immobilization and Upper Extremity Splinting Scott W. Eathorne, Todd M. Sheperd Cast immobilization is a technique used to treat a variety of medical conditions encountered by the…
CHAPTER 137 Colposcopic Examination Gary R. Newkirk Colposcopy is the examination of the cervix, vagina, and genital organs with light and magnification to identify abnormal areas for biopsy, so that…
