Peripheral Nerve Amyloidosis

May 14, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Peripheral Nerve Amyloidosis

Fig. 31.1 Shown are the characteristic features of amyloid deposition in peripheral sural nerve biopsy tissue studied by light microscopy. Paraffin-stained sections show an acellular and homogenous proteinaceous material on…

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Options for Amyloid Typing in Renal Pathology: The Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations Regarding Immunohistochemistry Methods

May 14, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Options for Amyloid Typing in Renal Pathology: The Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations Regarding Immunohistochemistry Methods

Fig. 20.1 A case of AL-lambda. (a) Stain for lambda light chain. Notice the high signal-to noise ratio. (b) Stain for kappa light chain. Although the exposure had to be…

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Diagnosis of Minimal Amyloid Deposits by Congo Red Fluorescence and Amyloid Type-Specific Immunohistochemistry: A Review

May 14, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Diagnosis of Minimal Amyloid Deposits by Congo Red Fluorescence and Amyloid Type-Specific Immunohistochemistry: A Review

Fig. 14.1 Diagnosis of amyloid in fixed tissues after CR staining, as viewed under three different types of illumination (“triple illumination”), in order to demonstrate the detection of amyloid and…

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Typing of Amyloid for Routine Use on Formalin-Fixed Paraffin Sections of 626 Patients by Applying Amyloid type-Specific Immunohistochemistry: A Review

May 14, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Typing of Amyloid for Routine Use on Formalin-Fixed Paraffin Sections of 626 Patients by Applying Amyloid type-Specific Immunohistochemistry: A Review

Amyloid class No. of patients % of total ALλ 271 43.3 ALκ 118 18.8 (AL, sum) (389) (62.1) ATTR 93 14.9 AA 80 12.8 AFib 14 2.2 Aβ2M 11 1.8…

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AA Amyloidosis

May 14, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on AA Amyloidosis

Disease Gene Inheritance Flare duration Fever Cutaneous manifestations Abdominal manifestations Pulmonary Arthritis arthralgias Neurologic AA Amyloidosis FMF MEFV AR 1–3 days Yes Erysipeloid erythema Pain, constipation, diarrhea Pleurisy Yes No…

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Generic Diagnosis of Amyloid: A Summary of Current Recommendations and the Editor’s Comments on Chapters 13–16

May 14, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Generic Diagnosis of Amyloid: A Summary of Current Recommendations and the Editor’s Comments on Chapters 13–16

Fig. 17.1 Fat needle biopsy. Congo red-stained slide viewed under polarized light showing apple green as well as yellow anomalous colors. Specimen obtained using a 16-gauge needle (Reprinted with permission…

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Clinical and Pathologic Issues in Patients with Amyloidosis: Summary and Practical Comments Regarding Diagnosis, Therapy, and Solid Organ Transplantation

May 14, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Clinical and Pathologic Issues in Patients with Amyloidosis: Summary and Practical Comments Regarding Diagnosis, Therapy, and Solid Organ Transplantation

Fig. 36.1 An algorithm for the evaluation of suspected amyloidosis [2]. Reprinted with permission. © 2008 American Society of Clinical Oncology. All rights reserved. Merlini G et al. J Clin…

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