Fig. 31.1 Shown are the characteristic features of amyloid deposition in peripheral sural nerve biopsy tissue studied by light microscopy. Paraffin-stained sections show an acellular and homogenous proteinaceous material on…
Fig. 20.1 A case of AL-lambda. (a) Stain for lambda light chain. Notice the high signal-to noise ratio. (b) Stain for kappa light chain. Although the exposure had to be…
Fig. 14.1 Diagnosis of amyloid in fixed tissues after CR staining, as viewed under three different types of illumination (“triple illumination”), in order to demonstrate the detection of amyloid and…
Amyloid class No. of patients % of total ALλ 271 43.3 ALκ 118 18.8 (AL, sum) (389) (62.1) ATTR 93 14.9 AA 80 12.8 AFib 14 2.2 Aβ2M 11 1.8…
Fig. 24.1 Virtual 2D map, showing the distribution of proteins identified by LC-MS in a representative subcutaneous fat tissue aspirate, according to isoelectric point and molecular weight. The inset and…
Disease Gene Inheritance Flare duration Fever Cutaneous manifestations Abdominal manifestations Pulmonary Arthritis arthralgias Neurologic AA Amyloidosis FMF MEFV AR 1–3 days Yes Erysipeloid erythema Pain, constipation, diarrhea Pleurisy Yes No…
Type Pathology Genetics Clinical Aβ Diffuse plaques Neuritic plaques/NFTs CAA (mild) Down’s AβPP Swe690/691 AβPP V717 Dementia Aβ CAA (severe) AβPP Dutch mutations Lobar hemorrhages, ± dementia BR12 Plaques, NFTs,…
Fig. 17.1 Fat needle biopsy. Congo red-stained slide viewed under polarized light showing apple green as well as yellow anomalous colors. Specimen obtained using a 16-gauge needle (Reprinted with permission…
Fig. 36.1 An algorithm for the evaluation of suspected amyloidosis [2]. Reprinted with permission. © 2008 American Society of Clinical Oncology. All rights reserved. Merlini G et al. J Clin…
Fig. 25.1 (a) Protein Electrophoresis (PEL) and Immunofixation electrophoresis (IFE) of normal serum: the proteins in the gamma fraction on the PEL gel and the precipitated immunoglobulins on the IFE…
