Fig. 19.1 Renal biopsy diagnosed MCD showing amyloid deposition with Congo red staining Another diagnosis that may cause difficulty is that of light chain deposition disease (LCDD). Of late, we…
Fig. 9.1 (a) Amyloidosis, fibrils. (b, c) Fibrillary glomerulonephritis, fibrils. (a, b, c) Transmission electron microscopy. Uranyl acetate and lead citrate. **AX8500, BX8500. In both conditions (a, b), the fibrils…
Fig. 26.1 H&E-stained (a) normocellular bone marrow (60 % cellularity) from a 41-year-old woman with AL amyloidosis and (b) normal hematopoietic bone marrow exhibiting normal maturation of myeloid and erythroid…
Pathology Extracellular Intracellular Intra-vascular Organized Non-organized Renal Extrarenal Light chain cast nephropathy +a Amorphous + − AL/AH amyloid + Fibrillar Congo red (+) + S/L MIDD + Powdery +…
Year Reference Type of amyloid Controls Amyloid patients Sensitivity (%) Specificity (%) PPV (%) NPV (%) 1986 [15] A, L, TTR 12 12 83 100 100 86 1987 [16] A…
Fig. 28.1 Renal amyloid deposits—Congo red stains viewed under polarized light. (a) Glomerular and extraglomerular vessels and interstitial amyloid. (b) Glomerular deposits. (c) Interstitial amyloid. (d) Amyloid in the medullary…
Shotgun proteomics Targeted proteomics Tries to identify every protein in a mixture Tries to identify specific protein targets Analogous to gene expression profiling Analogous to RTPCR or immunoassays Semiquantitative Quantitative…
Fig. 10.1 Nodular glomerulosclerosis secondary to κ-LCDD. (a) X500 and (b) X750. (a) Hematoxylin and eosin and (b) immunohistochemical stain for κ-light chains. (a) The glomerulus displays the typical nodularity—nodular…
Fig. 32.1 Gross appearances of lymph node involvement in AL amyloidosis. Cut surface of the lymph node involved by AL amyloidosis shows replacement of the parenchyma with a waxy appearing…
Fig. 33.1 Systemic ATTR amyloidosis involving the lung. Eosinophilic amorphous material consistent with vascular amyloid deposition in the lung (a, H&E, arrow) stained with Congo red (b, arrow). Congo red…
