Peripheral Nerve and Skeletal Muscle
27 Peripheral Nerve and Skeletal Muscle PBD7 and PBD8 Chapter 27: Peripheral Nerve and Skeletal Muscle BP7 and BP8 Chapter 21: The Musculoskeletal System 1 A 5-year-old boy develops increasing…
Tissue Renewal and Repair: Regeneration, Healing, and Fibrosis
3 Tissue Renewal and Repair: Regeneration, Healing, and Fibrosis PBD7 Chapter 3: Tissue Renewal and Repair: Regeneration, Healing, and Fibrosis PBD8 Chapter 3: Tissue Renewal, Regeneration, and Repair BP7 Chapter…
The Pancreas
19 The Pancreas PBD7 and PBD8 Chapter 19: The Pancreas BP7 and BP8 Chapter 17: The Pancreas 1 A 73-year-old woman has noticed a 10-kg weight loss in the past…
Amyloidosis of the Gastrointestinal Tract and Liver
Diarrhea Hematochezia or hematemesis Obstipation Obstruction or pseudo-obstruction Perforation Malabsorption Fig. 30.1 A patient with systemic amyloid and macroglossia. The tongue protrudes at the corners of the mouth and indentation…
The Hereditary Amyloidoses
Protein cDNA changea Amino acid changeb Codon change Clinical features Transthyretin Greater than 120 mutations c Apolipoprotein AI 148G→C Gly26Arg GGC26CGC PN, Nephropathy 172G→A Glu34Lys GAA34AAA Nephropathy 178T→G Ser36Ala…
The Role of Immuno-Electron Microscopy in Amyloid Typing: The Experience of the Pavia Referral Center
Fig. 22.1 Abdominal fat aspirate. In the middle a bundle of collagen fibers is seen and on the left, a lipid droplet in the cytoplasm of an adipocyte. Uranyl acetate,…
Cardiac Amyloidosis
Fig. 29.1 Isolated atrial amyloid. Autopsy examination showed slight rigidity of the left atrial wall. (a) The cardiac myocytes show hypertrophy but no distinct eosinophilic infiltrate in the interstitial space…
Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System
Main location Amyloid protein Mother protein Prevalence Associated state or disease Different organs AL Monoclonal immunoglobulin light chain Rare Local monoclonal plasma cell clone Different organs AH Monoclonal immunoglobulin heavy…
Diagnosis of Amyloid Using Congo Red
Fig. 13.1 An artery containing amyloid stained by Congo red. In ordinary, unpolarised illumination, amyloid appears red Even with satisfactory staining by Congo red, there may be staining of normal…
