Study—Neuraminidase Inhibitors and the Influenza Virus
The influenza pandemic of 1918 caused the deaths of many tens of millions of people worldwide. Later pandemics in 1957 and 1968 were only somewhat less catastrophic, causing around a…
Study—Drugs That Form a Covalent Bond to Their Target
We have seen in this chapter that some cancer drugs exert their cytotoxic effects by forming covalent bonds with their target (e.g., the reaction of mechlorethamine with DNA bases). A…
Study—Racemic and Non-Racemic Drugs
Currently, about 80% of the new drug molecules approved for clinical use are chiral, and of these, the vast majority are developed and marketed as single enantiomers. This was not…
Study—Inhibitors of Factor Xa as Anticoagulants
In this chapter we have discussed a wide variety of intermolecular interactions that can play a role in the binding of a drug to its target. In this case study…
