Stereochemistry
CHAPTER OUTLINE 3.1 Introduction 3.2 Chirality and the Shape of Molecules 3.3 Stereoisomers—Some Important Definitions Box 3.1—Determining isomeric and stereochemical relationships between molecules 3.4 Avoiding Confusion 3.5 Stereoisomers of 1,3-Dimethylcyclohexane 3.6 Chirality Centers 3.7 Assigning the Configuration…
Study—Calicheamicin γ1
Calicheamicin γ1 is a naturally occurring antibiotic and one of the most potent cellular toxins known (Figure 8.19). A single molecule of calicheamicin γ1, after entering a cell and cleaving…
Study—Discovery of Tagamet
Gastric acid in the stomach (primarily hydrochloric acid) is essential to digest protein and emulsify fats. It breaks down food so it can go on to the small intestines where…
Study—Odanacatib
Cathepsin K is one member of a family of cysteine proteases that employ an active-site cysteine residue to promote peptide bond cleavage. Cathepsin K is highly expressed in the osteoclast…
