Problem 7.2 In each of the reactions below, two related starting materials are shown. In each case, which of the two starting materials will react more rapidly? What is the structure of the product of the reaction?
Problem 7.3 On the left below is the partial structure of azilsartan medoxomil, a prodrug of azilsartan shown on the far right. A simple methyl ester of the drug is too sterically hindered to undergo hydrolysis by esterases, but the more accessible cyclic carbonate in the prodrug is readily hydrolyzed. Write a mechanism for the hydrolysis of the cyclic carbonate at the indicated pH.
Problem 7.4
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