INTRODUCTION Before the discovery of general anesthetics, pain and shock severely limited the possibilities for surgical intervention. Postoperative mortality dropped dramatically following the first public demonstration of diethyl ether at…
INTRODUCTION Even the most promising of pharmacologic therapies will fail in clinical trials if the drug is unable to reach its target organ at a concentration sufficient to have a…
INTRODUCTION Cancer therapy has traditionally been based on the principle that tumor cells are traversing the cell cycle frequently and are thus more sensitive than normal cells to interference with…
INTRODUCTION Blood carries oxygen and nutrients to tissues and takes metabolic waste products away from tissues. Humans have developed a well-regulated system of hemostasis to keep the blood fluid and…
Pharmacology of Eicosanoids David M. Dudzinski and Charles N. Serhan INTRODUCTION & CASE PHYSIOLOGY OF EICOSANOID METABOLISM Generation of Arachidonic Acid and Omega-3 Fatty Acids Cyclooxygenase Pathway Prostaglandins Thromboxane and…
INTRODUCTION In Chapters 20–25, cardiovascular pharmacology is considered in the context of individual physiologic systems. For example, diuretics are discussed in the context of volume regulation, while inhibitors of angiotensin…
Pharmacology of Viral Infections Jonathan Z. Li and Donald M. Coen INTRODUCTION & CASE PHYSIOLOGY OF VIRAL REPLICATION Viral Life Cycle PHARMACOLOGIC CLASSES AND AGENTS Inhibition of Viral Attachment and…
INTRODUCTION The human heart is both a mechanical and an electrical organ. To perfuse the body adequately with blood, the mechanical and electrical components of the heart must work in…
INTRODUCTION Over the past decade, the US Food and Drug Administration (FDA) has approved approximately 260 new therapeutics, including 220 new molecular entities (small molecules) and 42 biotherapeutics (generally, recombinant…
