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Fig. 10.1 Reactive type II pneumocytes in a bronchoalveolar lavage specimen. Markedly enlarged nuclei, prominent nucleoli, and abundant vacuolated cytoplasm (cytospin, Papanicolaou stain) Morphologic features that favor RPII over malignant…

  TTF-1 Napsin A CK7 Surfactant A protein Overalla Sensitivity 76 77.8 97 61.8 Specificity 95.9 98.1 68.8 97 Biopsy and cytologyb Sensitivity 76.1 69.1 100 80.6 Specificity 94.2 96.1…

Fig. 7.1 Scoring system for immunostaining of small biopsy specimens with mutation-specific EGFR antibodies—L858R mutation in exon 21 and 15-bp deletion in exon 19. (a and b) Negative scores. (a)…

Fig. 4.1 Algorithm for procuring fine needle aspirations with rapid on-site evaluation (ROSE): The algorithm for optimizing FNAs with ROSE is divided into 3 main categories: (1) specimen procurement and…

Fig. 1.1 Photographs of H&E-stained slides diagnosed as adenocarcinoma in core biopsy specimens. (a) Adenocarcinoma with papillary pattern (original magnification × 100). (b) Adenocarcinoma with micropapillary pattern (original magnification × 200). As per current…

Fig. 8.1 Frequency of oncogenic drivers in lung adenocarcinoma as part of the Lung Cancer Mutation Consortium The opportunities for potential therapeutic targets in SQCLC were supported by the observation…

Fig. 3.1 Practice gap. Currently, there is no standardized algorithm for optimal procurement, processing, and triaging of small specimens Since diagnoses are based more frequently on small biopsy and/or cytology…

Fig. 6.1 (a) Scanned cell block preparation slide of a lung fine-needle aspiration (FNA). (b) Formalin-fixed paraffin-embedded cell block preparation slide with high cellularity. (c) The inset shows EGFR exon…

Sampling technique Site(s) accessible Staging procedure Real-time imaging and sampling Complication risk Specimen(s) attainable Wang Central Yes No + FNA and biopsy Radial EBUS Central and peripheral Yesa No +…