81 New Terminology82 Protein Allosterism82 Types of Allosteric Modulators84 Unique Effects of Allosteric Modulators87 Detecting Allosterism93 Quantifying Allosteric Effect98 Descriptive Pharmacology: V101 Summary102 This chapter begins with a discussion of…
37 New Terminology39 The Black–Leff Operational Model of Agonism40 Applying the Black–Leff Model to Predict Agonism43 Descriptive Pharmacology: III49 Summary50 This chapter discusses the use of the Black–Leff operational model…
211 New Terminology212 Safety Versus Toxicity212 Safety Pharmacology214 Early Safety Tests219 Hepatic Toxicity223 Summary225 The main aim of safety pharmacology is to define the optimal way in which potentially valuable…
The Chemical Control of Physiology Outline Pharmacology and Cellular Drug Response1 New Terminology2 Pharmacological Targets2 Dose–Response Curves5 Linking Observed Pharmacology With Molecular Mechanism12 Descriptive Pharmacology: I15 Summary16 This chapter discusses…
DRUG CLASSES Posterior pituitary hormones • Vasopressin Anterior pituitary hormones • Gonadotropins • Somatropin • Adrenocorticotropic hormone (ACTH) Glucocorticoids Mineralocorticoids PHARMACOLOGY IN PRACTICE Janna Wong is at the clinic for a sports physical. As…
DRUG CLASSES Cell cycle–specific agents • Plant alkaloids • Taxanes • Podophyllotoxins • Camptothecin analogs • Antimetabolites Cell cycle–nonspecific agents • Alkylates • Ethyleneimines • Alkyl sulfonates • Hydrazines • Nitrosoureas • Platinum based • Antibiotics PHARMACOLOGY IN PRACTICE Patients and families…
DRUG CLASSES Otic preparations Ophthalmic Preparations PHARMACOLOGY IN PRACTICE Janna Wong, a 16-year-old high school student, recently switched from eyeglasses to contact lenses. She is experiencing minor eye irritation. In…
DRUG CLASSES Insulins Sulfonylureas Nonsulfonylureas Incretin mimetics PHARMACOLOGY IN PRACTICE When Mr. Phillip was seen for atrial fibrillation, it was discovered that he had not been seen by a health…
DRUG CLASSES Female hormones • Estrogens • Progestins Antispasmodics Benign prostatic Hyperplasia (BPH) Agents • α-adrenergic blockers • Androgen hormone Inhibitors • Impotence agents Hormonal cancer agents In both men…
DRUG CLASSES Androgens Estrogens Progestins PHARMACOLOGY IN PRACTICE Janna Wong is at the clinic for a sports physical. After the physical, Janna lingers in the examination room. You knock and…
