Congenital Nevi
and Victor G. Prieto2 (1) Division of Dermatopathology, Miraca Life Sciences, Dallas, TX, USA (2) MD Anderson Cancer Center, University of Texas, Houston, TX, USA Congenital Melanocytic Nevi Introduction Congenital melanocytic…
Evaluation of Small Biopsy Material in Patients with Multiple and Secondary Tumors
Criteria AJCC staging, 7th edition Primary lung tumor with intrapulmonary metastases Similar morphology and molecular characteristics T3: Additional nodules in the same lobe are considered T3 T4: Additional tumors…
Mimickers of Lung Carcinoma in Cytology and Small Biopsy Specimens
Fig. 10.1 Reactive type II pneumocytes in a bronchoalveolar lavage specimen. Markedly enlarged nuclei, prominent nucleoli, and abundant vacuolated cytoplasm (cytospin, Papanicolaou stain) Morphologic features that favor RPII over malignant…
Ancillary Immunohistochemical Techniques for the Subclassification of Non-small Cell Lung Cancer
TTF-1 Napsin A CK7 Surfactant A protein Overalla Sensitivity 76 77.8 97 61.8 Specificity 95.9 98.1 68.8 97 Biopsy and cytologyb Sensitivity 76.1 69.1 100 80.6 Specificity 94.2 96.1…
Role of Immunohistochemistry in the Detection of Targetable Mutations
Fig. 7.1 Scoring system for immunostaining of small biopsy specimens with mutation-specific EGFR antibodies—L858R mutation in exon 21 and 15-bp deletion in exon 19. (a and b) Negative scores. (a)…
Optimization and Triage of Small Specimens
Fig. 4.1 Algorithm for procuring fine needle aspirations with rapid on-site evaluation (ROSE): The algorithm for optimizing FNAs with ROSE is divided into 3 main categories: (1) specimen procurement and…
Histologic Classification and Its Need for Treatment of Lung Cancer
Fig. 1.1 Photographs of H&E-stained slides diagnosed as adenocarcinoma in core biopsy specimens. (a) Adenocarcinoma with papillary pattern (original magnification × 100). (b) Adenocarcinoma with micropapillary pattern (original magnification × 200). As per current…
New Discoveries for the Treatment of Lung Cancer and the Role of Small Biopsy Material
Fig. 8.1 Frequency of oncogenic drivers in lung adenocarcinoma as part of the Lung Cancer Mutation Consortium The opportunities for potential therapeutic targets in SQCLC were supported by the observation…
Adequacy and Tissue Preservation of Small Biopsy and Cytology Specimens
Fig. 3.1 Practice gap. Currently, there is no standardized algorithm for optimal procurement, processing, and triaging of small specimens Since diagnoses are based more frequently on small biopsy and/or cytology…
Adequacy and Utilization of Small Biopsy Material for Molecular Diagnosis
Fig. 6.1 (a) Scanned cell block preparation slide of a lung fine-needle aspiration (FNA). (b) Formalin-fixed paraffin-embedded cell block preparation slide with high cellularity. (c) The inset shows EGFR exon…
