Antibodies Discussed | |||
Antibody Name/Symbol |
Antibody Description |
Clones/Alternative Names |
Chapters |
β-2-microglobulin |
component of MHC class I molecules |
B2-MICROGLB |
Amyloidoma |
β-catenin |
beta catenin; involved in regulation of cell adhesion and in signal transduction through Wnt pathway |
B-catenin, CLONE 14, E-5, RB-9035Po, 17C2, 5H10 |
Desmoplastic Fibroma; Solitary Fibrous Tumor/Hemangiopericytoma |
Actin-sm |
actin, smooth muscle |
SMA, ASM-1, CGA7, 1A4, HUC1-1 |
Chondromyxoid Fibroma; Myoepithelioma; Myofibroma and Myofibromatosis; Phosphaturic Mesenchymal Tumor |
AE1/AE3 |
mixture of 2 anticytokeratin clones that detect a variety of both high- and low-molecular weight cytokeratins |
Adamantinoma; Benign Notochordal Cell Tumor; Chordoma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Phosphaturic Mesenchymal Tumor | |
ALK |
anaplastic lymphoma kinase-1 |
5A4, ALK1, ALKC |
Primary Lymphoma |
Amyloid fibril protein AA |
acute-phase protein associated with many chronic inflammatory conditions |
AA-protein, SAA1 |
Amyloidoma |
Bcl-2 |
B-cell lymphoma 2; suppresses apoptosis in a variety of cell systems |
ONCL2, BCL2/100/D5, 124, 124.3 |
Solitary Fibrous Tumor/Hemangiopericytoma |
Brachyury |
crucial regulator of notochordal development and biomarker for chordomas |
Benign Notochordal Cell Tumor; Chordoma; Conventional Chondrosarcoma; Ecchordosis; Epithelioid Hemangioendothelioma; Myxopapillary Ependymoma | |
C-Kit |
tyrosine-protein kinase activity |
CD117, C-19 (C-KIT), 104D2, 2E4, CKIT, A4502, H300, CMA-767 |
Mast Cell Disease |
Carcinoembryonic antigen |
CEA-M, mCEA, CEA-B18, CEA-D14, CEAGOLD 1, T84.6, CEA-GOLD 2, CEA 11, CEA-GOLD 3, CEA 27, CEAGOLD 4, CEA 41, CEA-GOLD 5, T84.1, CEA-M, A5B7, CEJ065, IL-7, T84.66, TF3H8-1, 0062, D14, alpha-7, PARLAM 1, ZC23, CEM010, A115, COL-1, AF4, 12.140.10, 11-7, M773, CEAM431_ 31, CEJO65 |
Chordoma | |
CD1a |
T-cell surface glycoprotein |
JPM30, CD1A, O10, NA1/34 |
Erdheim-Chester Disease; Langerhans Cell Histiocytosis (Eosinophilic Granuloma); Rosai-Dorfman Disease |
CD10 |
neutral endopeptidase |
NCL-270, CALLA, neprilysin, neutral endopeptidase, NEP |
Metastatic Tumors; Plasmacytoma/Myeloma |
CD19 |
B-cell antigen |
Plasmacytoma/Myeloma | |
CD20 |
tumor necrosis factor SF8 |
BER-H2, KI-1, TNFRSF8 |
Primary Lymphoma |
CD25 |
If-2 receptor alpha |
2A3, 4C9 |
Mast Cell Disease |
CD31 |
platelet endothelial cell adhesion molecule |
JC/70, JC/70A, PECAM-1 |
Angiosarcoma; Conventional Hemangioma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Metastatic Tumors |
CD34 |
hematopoietic progenitor cell antigen |
MY10, IOM34, QBEND10, 8G12, 1309, HPCA-1, NU-4A1, TUK4, clone 581, BI-3c5 |
Angiosarcoma; Conventional Hemangioma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Metastatic Tumors; Myoepithelioma; Myofibroma and Myofibromatosis; Phosphaturic Mesenchymal Tumor; Solitary Fibrous Tumor/Hemangiopericytoma |
CD56 |
NCAM (neutral cellular adhesion molecule) |
MAB735, ERIC-1, 25-KD11, 123C3, 24-MB2, BC56C04, 1B6, 14-MAB735, NCC-LU-243, MOC-1, NCAM |
Plasmacytoma/Myeloma |
CD57 |
β-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) |
LEU-7, NK1, HNK-1, TB01, B3GAT1 |
Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET) |
CD68 |
cytoplasmic granule protein of monocytes, macrophages |
PG-M1, KP-1 |
Erdheim-Chester Disease; Rosai-Dorfman Disease |
CD99 |
cell surface glycoprotein for migration, T-cell adhesion, MIC2 |
CD99-MEMB, MIC2, 12E7, HBA71, O13, P30/32MIC2, M3601 |
Conventional Osteosarcoma; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Mesenchymal Chondrosarcoma; Solitary Fibrous Tumor/Hemangiopericytoma |
CD117 |
C-kit, tyrosine-protein kinase activity |
C-19 (C-KIT), 104D2, 2E4, C-KIT, A4502, H300, CMA-767 |
Mast Cell Disease; Plasmacytoma/Myeloma |
CD163 |
macrophage hemoglobin scavenging system |
10D6 |
Erdheim-Chester Disease; Rosai-Dorfman Disease |
CDK4 |
cyclin dependent kinase 4 |
C-22, DCS-31 |
Adipocytic Tumors; Desmoplastic Fibroma; Fibrous Dysplasia; Well-Differentiated Intramedullary Osteosarcoma |
CK-PAN |
cytokeratin-pan (AE1/AE3/LP34); cocktail of high- and low-molecular weight cytokeratins |
keratin pan, MAK-6, K576, LU-5, KL-1, KC-8, MNF 116, pankeratin, pancytokeratin |
Angiosarcoma; Ecchordosis; Osteofibrous Dysplasia |
Collagen II |
major component of articular and hyaline cartilage |
Chondroblastoma; Chondromyxoid Fibroma; Clear Cell Chondrosarcoma | |
Collagen III |
CIV22, COL4A [1-5], collagen α-1(IV) chain |
COL3A1, Collagen alpha 1(III) chain, Collagen III alpha 1 chain precursor, Collagen III alpha 1 polypeptide, Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant), Collagen type III alpha 1, Collagen type III alpha, EDS4A, Ehlers Danlos syndrome type IV, autosomal dominant; Fetal collagen, Type III collagen |
Chondromyxoid Fibroma |
Collagen IV |
major constituent of the basement membranes along with laminins, proteoglycans, and enactins |
CIV22, COL4A [1-5], collagen α-1(IV) chain |
Chodromyxoid Fibroma |
COX-2 |
cyclooxygenase-2 |
CX229, CLONE 33, COX-2-P |
Osteoid Osteoma |
Cytokeratin |
Ecchordosis | ||
D2-40 |
marker for reactive follicular dendritic cells and follicular dendritic cell sarcomas |
podoplanin, M2A |
Dedifferentiated Chondrosarcoma; Lymphangioma/Lymphangiomatosis |
Desmin |
class III intermediate filaments found in muscle cells |
M760, DE-R-11, D33, DE5, DE-U-10, ZC18 |
Epithelioid Hemangioendothelioma; Fibrosarcoma (Malignant Fibrous Histiocytoma); Leiomyosarcoma; Melanotic Neuroectodermal Tumor; Mesenchymal Chondrosarcoma; Myoepithelioma; Phosphaturic Mesenchymal Tumor; Solitary Fibrous Tumor/Hemangiopericytoma |
EMA |
epithelial membrane antigen |
GP1.4, 214D4, MC5, E29 |
Chordoma; Fibrous Dysplasia; Mesenchymal Chondrosarcoma; Myoepithelioma |
Epithelial membrane antigen |
EMA, GP1.4, 214D4, MC5, E29 |
Angiosarcoma; Chondroblastoma; Chordoma; Conventional Osteosarcoma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Myoepithelioma; Solitary Fibrous Tumor/Hemangiopericytoma | |
Factor VIII-related antigen |
FVIIIRAg, F8/86, von Willenbrand factor |
Angiosarcoma; Conventional Hemangioma | |
FGF23 |
fibroblast growth factor 23 |
Phosphaturic Mesenchymal Tumor; Solitary Fibrous Tumor/Hemangiopericytoma | |
Fibrin |
mouse IgG antibody against β chain of fibrin that recognizes both murine and human fibrin |
Aneurysmal Bone Cyst; Fibrous Dysplasia; Giant Cell Tumor; Unicameral Bone Cyst | |
Fibroblast growth factor 23 |
FGF23 |
Phosphaturic Mesenchymal Tumor | |
FLI-1 |
Friend leukemia virus integration 1 |
EWSR2, GI146-222, SC356, FLK-1, FLT-1 |
Angiosarcoma; Conventional Hemangioma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Mesenchymal Chondrosarcoma |
FVIIIRAg |
factor VIII-related antigen |
FVIIIRAG, F8/86, von Willebrand factor |
Epithelioid Hemangioendothelioma |
Glial fibrillary acidic protein |
intermediate filament expressed by numerous cells of the CNS |
6F2, M761, GA-51, GFP-8A |
Chordoma; Melanotic Neuroectodermal Tumor; Myoepithelioma |
HMB-45 |
antigen present in melanocytic tumors such as melanomas |
LB39 AA, CMM1, CMM, DNS, FAMMM, Mart1, Melan-A, MLM, tyrosinase |
Melanotic Neuroectodermal Tumor |
Immunoglobulin A |
IgA, IGA |
Plasmacytoma/Myeloma | |
Kappa light chain |
KAPPA, κ light chain |
Plasmacytoma/Myeloma | |
Ki-67 |
Ki-67 (MIB-1); marker of cell proliferation |
MMI, KI88, IVAK-2, MIB1 |
Conventional Chondrosarcoma |
Lambda light chain |
λ light chain, LAMBDA |
Plasmacytoma/Myeloma | |
Langerin |
CD207 molecule |
CD207 |
Erdheim-Chester Disease; Langerhans Cell Histiocytosis (Eosinophilic Granuloma); Rosai-Dorfman Disease |
LCA |
leukocyte common antigen |
PD7/26, 1.22/4.14, T29/33, CD45RB, RP2/18, CD45, PD7, 2D1, 2B11+PD7/26 |
Primary Lymphoma |
LEU-7 |
β-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) |
CD57, NK1, HNK-1, TB01, B3GAT1 |
Mesenchymal Chondrosarcoma |
Leukocyte common antigen |
LCA, PD7/26, 1.22/4.14, T29/33, CD45RB, RP2/18, CD45, PD7, 2D1, 2B11+PD7/26 |
Primary Lymphoma | |
MDM2 |
murine double minute oncogene (mdm2) |
HDM2, IF2, 2A10, 1B10, SMP14, murine double minute 2 |
Adipocytic Tumors; Desmoplastic Fibroma; Fibrous Dysplasia; Melorheostosis; Well-Differentiated Intramedullary Osteosarcoma |
MYOD1 |
myogenic differentiation 1 |
5.8A, 5.2F |
Mesenchymal Chondrosarcoma |
Myogenin |
F5D, MYF3, MYF4, MYOGENIN, LO26 |
Mesenchymal Chondrosarcoma | |
N-myc |
protooncogene and member of the MYC family of transcription factors |
Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET) | |
NSE |
neuron specific enolase |
BSS/H14 |
Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET) |
p63 |
tumor protein p63 |
P63-P53 Homologous Nuclear Protein; Delta-NP63, 4A4, P63, H-137, 7JUL |
Chondroblastoma; Giant Cell Reparative Granuloma; Giant Cell Tumor; Myoepithelioma |
PSA |
prostate specific antigen |
PSA-M, PSA, ER-PR8, PSA-P, F5 |
Metastatic Tumors |
PSAP |
prostatic specific acid phosphatase |
PAP, PASE/4LJ, PAP-P |
Metastatic Tumors |
RCC |
renal cell carcinoma |
66.4C2, PN-15, RCC, RCC MA |
Metastatic Tumors |
S100 |
Low molecular weight protein normally present in cells derived from neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes |
S-100, A6, 15E2E2, Z311, 4C4.9, S100 protein |
Adipocytic Tumors; Benign Notochordal Cell Tumor; Chondroblastoma; Chondromyxoid Fibroma; Chordoma; Clear Cell Chondrosarcoma; Conventional Chondrosarcoma; Conventional Osteosarcoma; Ecchordosis; Enchondroma; Epithelioid Hemangioendothelioma; Erdheim-Chester Disease; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Giant Cell Tumor; Langerhans Cell Histiocytosis (Eosinophilic Granuloma); Melanotic Neuroectodermal Tumor; Mesenchymal Chondrosarcoma; Myoepithelioma; Osteoid Osteoma; Phosphaturic Mesenchymal Tumor; Rosai-Dorfman Disease; Schwannoma; Solitary Fibrous Tumor/Hemangiopericytoma; Vascular Cartilaginous Hamartoma of Chest Wall |
SOX9 |
SRY (sex-determining region Y)-box 9 protein |
CMD1, CMPD1 |
Chondroblastoma; Chondromyxoid Fibroma; Mesenchymal Chondrosarcoma |
TdT |
terminal deoxynucleotidyl transferase |
SEN28 |
Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Primary Lymphoma |
Terminal deoxynucleotidyl transferase |
SEN28, TdT |
Primary Lymphoma | |
Thyroglobulin |
dimetric protein specific to thyroid gland |
DAK-TG6 |
Metastatic Tumors |
Tryptase |
serine proteinase contained in mast cells |
Mast Cell Disease | |
Vimentin |
major subunit protein of the intermediate filaments of mesenchymal cells |
43BE8, 3B4, V10, V9, VIM-3B4, VIM |
Enchondroma; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Fibrosarcoma (Malignant Fibrous Histiocytoma); Fibrous Dysplasia; Mesenchymal Chondrosarcoma; Myoepithelioma; Myofibroma and Myofibromatosis |

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