Antibody Index

Antibody Index

Antibodies Discussed

Antibody Name/Symbol

Antibody Description

Clones/Alternative Names

Chapters

β-2-microglobulin

component of MHC class I molecules

B2-MICROGLB

Amyloidoma

β-catenin

beta catenin; involved in regulation of cell adhesion and in signal transduction through Wnt pathway

B-catenin, CLONE 14, E-5, RB-9035Po, 17C2, 5H10

Desmoplastic Fibroma; Solitary Fibrous Tumor/Hemangiopericytoma

Actin-sm

actin, smooth muscle

SMA, ASM-1, CGA7, 1A4, HUC1-1

Chondromyxoid Fibroma; Myoepithelioma; Myofibroma and Myofibromatosis; Phosphaturic Mesenchymal Tumor

AE1/AE3

mixture of 2 anticytokeratin clones that detect a variety of both high- and low-molecular weight cytokeratins

Adamantinoma; Benign Notochordal Cell Tumor; Chordoma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Phosphaturic Mesenchymal Tumor

ALK

anaplastic lymphoma kinase-1

5A4, ALK1, ALKC

Primary Lymphoma

Amyloid fibril protein AA

acute-phase protein associated with many chronic inflammatory conditions

AA-protein, SAA1

Amyloidoma

Bcl-2

B-cell lymphoma 2; suppresses apoptosis in a variety of cell systems

ONCL2, BCL2/100/D5, 124, 124.3

Solitary Fibrous Tumor/Hemangiopericytoma

Brachyury

crucial regulator of notochordal development and biomarker for chordomas

Benign Notochordal Cell Tumor; Chordoma; Conventional Chondrosarcoma; Ecchordosis; Epithelioid Hemangioendothelioma; Myxopapillary Ependymoma

C-Kit

tyrosine-protein kinase activity

CD117, C-19 (C-KIT), 104D2, 2E4, CKIT, A4502, H300, CMA-767

Mast Cell Disease

Carcinoembryonic antigen

CEA-M, mCEA, CEA-B18, CEA-D14, CEAGOLD 1, T84.6, CEA-GOLD 2, CEA 11, CEA-GOLD 3, CEA 27, CEAGOLD 4, CEA 41, CEA-GOLD 5, T84.1, CEA-M, A5B7, CEJ065, IL-7, T84.66, TF3H8-1, 0062, D14, alpha-7, PARLAM 1, ZC23, CEM010, A115, COL-1, AF4, 12.140.10, 11-7, M773, CEAM431_ 31, CEJO65

Chordoma

CD1a

T-cell surface glycoprotein

JPM30, CD1A, O10, NA1/34

Erdheim-Chester Disease; Langerhans Cell Histiocytosis (Eosinophilic Granuloma); Rosai-Dorfman Disease

CD10

neutral endopeptidase

NCL-270, CALLA, neprilysin, neutral endopeptidase, NEP

Metastatic Tumors; Plasmacytoma/Myeloma

CD19

B-cell antigen

Plasmacytoma/Myeloma

CD20

tumor necrosis factor SF8

BER-H2, KI-1, TNFRSF8

Primary Lymphoma

CD25

If-2 receptor alpha

2A3, 4C9

Mast Cell Disease

CD31

platelet endothelial cell adhesion molecule

JC/70, JC/70A, PECAM-1

Angiosarcoma; Conventional Hemangioma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Metastatic Tumors

CD34

hematopoietic progenitor cell antigen

MY10, IOM34, QBEND10, 8G12, 1309, HPCA-1, NU-4A1, TUK4, clone 581, BI-3c5

Angiosarcoma; Conventional Hemangioma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Metastatic Tumors; Myoepithelioma; Myofibroma and Myofibromatosis; Phosphaturic Mesenchymal Tumor; Solitary Fibrous Tumor/Hemangiopericytoma

CD56

NCAM (neutral cellular adhesion molecule)

MAB735, ERIC-1, 25-KD11, 123C3, 24-MB2, BC56C04, 1B6, 14-MAB735, NCC-LU-243, MOC-1, NCAM

Plasmacytoma/Myeloma

CD57

β-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

LEU-7, NK1, HNK-1, TB01, B3GAT1

Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)

CD68

cytoplasmic granule protein of monocytes, macrophages

PG-M1, KP-1

Erdheim-Chester Disease; Rosai-Dorfman Disease

CD99

cell surface glycoprotein for migration, T-cell adhesion, MIC2

CD99-MEMB, MIC2, 12E7, HBA71, O13, P30/32MIC2, M3601

Conventional Osteosarcoma; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Mesenchymal Chondrosarcoma; Solitary Fibrous Tumor/Hemangiopericytoma

CD117

C-kit, tyrosine-protein kinase activity

C-19 (C-KIT), 104D2, 2E4, C-KIT, A4502, H300, CMA-767

Mast Cell Disease; Plasmacytoma/Myeloma

CD163

macrophage hemoglobin scavenging system

10D6

Erdheim-Chester Disease; Rosai-Dorfman Disease

CDK4

cyclin dependent kinase 4

C-22, DCS-31

Adipocytic Tumors; Desmoplastic Fibroma; Fibrous Dysplasia; Well-Differentiated Intramedullary Osteosarcoma

CK-PAN

cytokeratin-pan (AE1/AE3/LP34); cocktail of high- and low-molecular weight cytokeratins

keratin pan, MAK-6, K576, LU-5, KL-1, KC-8, MNF 116, pankeratin, pancytokeratin

Angiosarcoma; Ecchordosis; Osteofibrous Dysplasia

Collagen II

major component of articular and hyaline cartilage

Chondroblastoma; Chondromyxoid Fibroma; Clear Cell Chondrosarcoma

Collagen III

CIV22, COL4A [1-5], collagen α-1(IV) chain

COL3A1, Collagen alpha 1(III) chain, Collagen III alpha 1 chain precursor, Collagen III alpha 1 polypeptide, Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant), Collagen type III alpha 1, Collagen type III alpha, EDS4A, Ehlers Danlos syndrome type IV, autosomal dominant; Fetal collagen, Type III collagen

Chondromyxoid Fibroma

Collagen IV

major constituent of the basement membranes along with laminins, proteoglycans, and enactins

CIV22, COL4A [1-5], collagen α-1(IV) chain

Chodromyxoid Fibroma

COX-2

cyclooxygenase-2

CX229, CLONE 33, COX-2-P

Osteoid Osteoma

Cytokeratin

Ecchordosis

D2-40

marker for reactive follicular dendritic cells and follicular dendritic cell sarcomas

podoplanin, M2A

Dedifferentiated Chondrosarcoma; Lymphangioma/Lymphangiomatosis

Desmin

class III intermediate filaments found in muscle cells

M760, DE-R-11, D33, DE5, DE-U-10, ZC18

Epithelioid Hemangioendothelioma; Fibrosarcoma (Malignant Fibrous Histiocytoma); Leiomyosarcoma; Melanotic Neuroectodermal Tumor; Mesenchymal Chondrosarcoma; Myoepithelioma; Phosphaturic Mesenchymal Tumor; Solitary Fibrous Tumor/Hemangiopericytoma

EMA

epithelial membrane antigen

GP1.4, 214D4, MC5, E29

Chordoma; Fibrous Dysplasia; Mesenchymal Chondrosarcoma; Myoepithelioma

Epithelial membrane antigen

EMA, GP1.4, 214D4, MC5, E29

Angiosarcoma; Chondroblastoma; Chordoma; Conventional Osteosarcoma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Myoepithelioma; Solitary Fibrous Tumor/Hemangiopericytoma

Factor VIII-related antigen

FVIIIRAg, F8/86, von Willenbrand factor

Angiosarcoma; Conventional Hemangioma

FGF23

fibroblast growth factor 23

Phosphaturic Mesenchymal Tumor; Solitary Fibrous Tumor/Hemangiopericytoma

Fibrin

mouse IgG antibody against β chain of fibrin that recognizes both murine and human fibrin

Aneurysmal Bone Cyst; Fibrous Dysplasia; Giant Cell Tumor; Unicameral Bone Cyst

Fibroblast growth factor 23

FGF23

Phosphaturic Mesenchymal Tumor

FLI-1

Friend leukemia virus integration 1

EWSR2, GI146-222, SC356, FLK-1, FLT-1

Angiosarcoma; Conventional Hemangioma; Epithelioid Hemangioendothelioma; Epithelioid Hemangioma; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Mesenchymal Chondrosarcoma

FVIIIRAg

factor VIII-related antigen

FVIIIRAG, F8/86, von Willebrand factor

Epithelioid Hemangioendothelioma

Glial fibrillary acidic protein

intermediate filament expressed by numerous cells of the CNS

6F2, M761, GA-51, GFP-8A

Chordoma; Melanotic Neuroectodermal Tumor; Myoepithelioma

HMB-45

antigen present in melanocytic tumors such as melanomas

LB39 AA, CMM1, CMM, DNS, FAMMM, Mart1, Melan-A, MLM, tyrosinase

Melanotic Neuroectodermal Tumor

Immunoglobulin A

IgA, IGA

Plasmacytoma/Myeloma

Kappa light chain

KAPPA, κ light chain

Plasmacytoma/Myeloma

Ki-67

Ki-67 (MIB-1); marker of cell proliferation

MMI, KI88, IVAK-2, MIB1

Conventional Chondrosarcoma

Lambda light chain

λ light chain, LAMBDA

Plasmacytoma/Myeloma

Langerin

CD207 molecule

CD207

Erdheim-Chester Disease; Langerhans Cell Histiocytosis (Eosinophilic Granuloma); Rosai-Dorfman Disease

LCA

leukocyte common antigen

PD7/26, 1.22/4.14, T29/33, CD45RB, RP2/18, CD45, PD7, 2D1, 2B11+PD7/26

Primary Lymphoma

LEU-7

β-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

CD57, NK1, HNK-1, TB01, B3GAT1

Mesenchymal Chondrosarcoma

Leukocyte common antigen

LCA, PD7/26, 1.22/4.14, T29/33, CD45RB, RP2/18, CD45, PD7, 2D1, 2B11+PD7/26

Primary Lymphoma

MDM2

murine double minute oncogene (mdm2)

HDM2, IF2, 2A10, 1B10, SMP14, murine double minute 2

Adipocytic Tumors; Desmoplastic Fibroma; Fibrous Dysplasia; Melorheostosis; Well-Differentiated Intramedullary Osteosarcoma

MYOD1

myogenic differentiation 1

5.8A, 5.2F

Mesenchymal Chondrosarcoma

Myogenin

F5D, MYF3, MYF4, MYOGENIN, LO26

Mesenchymal Chondrosarcoma

N-myc

protooncogene and member of the MYC family of transcription factors

Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)

NSE

neuron specific enolase

BSS/H14

Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)

p63

tumor protein p63

P63-P53 Homologous Nuclear Protein; Delta-NP63, 4A4, P63, H-137, 7JUL

Chondroblastoma; Giant Cell Reparative Granuloma; Giant Cell Tumor; Myoepithelioma

PSA

prostate specific antigen

PSA-M, PSA, ER-PR8, PSA-P, F5

Metastatic Tumors

PSAP

prostatic specific acid phosphatase

PAP, PASE/4LJ, PAP-P

Metastatic Tumors

RCC

renal cell carcinoma

66.4C2, PN-15, RCC, RCC MA

Metastatic Tumors

S100

Low molecular weight protein normally present in cells derived from neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes

S-100, A6, 15E2E2, Z311, 4C4.9, S100 protein

Adipocytic Tumors; Benign Notochordal Cell Tumor; Chondroblastoma; Chondromyxoid Fibroma; Chordoma; Clear Cell Chondrosarcoma; Conventional Chondrosarcoma; Conventional Osteosarcoma; Ecchordosis; Enchondroma; Epithelioid Hemangioendothelioma; Erdheim-Chester Disease; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Giant Cell Tumor; Langerhans Cell Histiocytosis (Eosinophilic Granuloma); Melanotic Neuroectodermal Tumor; Mesenchymal Chondrosarcoma; Myoepithelioma; Osteoid Osteoma; Phosphaturic Mesenchymal Tumor; Rosai-Dorfman Disease; Schwannoma; Solitary Fibrous Tumor/Hemangiopericytoma; Vascular Cartilaginous Hamartoma of Chest Wall

SOX9

SRY (sex-determining region Y)-box 9 protein

CMD1, CMPD1

Chondroblastoma; Chondromyxoid Fibroma; Mesenchymal Chondrosarcoma

TdT

terminal deoxynucleotidyl transferase

SEN28

Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Primary Lymphoma

Terminal deoxynucleotidyl transferase

SEN28, TdT

Primary Lymphoma

Thyroglobulin

dimetric protein specific to thyroid gland

DAK-TG6

Metastatic Tumors

Tryptase

serine proteinase contained in mast cells

Mast Cell Disease

Vimentin

major subunit protein of the intermediate filaments of mesenchymal cells

43BE8, 3B4, V10, V9, VIM-3B4, VIM

Enchondroma; Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Fibrosarcoma (Malignant Fibrous Histiocytoma); Fibrous Dysplasia; Mesenchymal Chondrosarcoma; Myoepithelioma; Myofibroma and Myofibromatosis

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Jul 6, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Antibody Index

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