Angiomatosis
David R. Lucas, MD
Key Facts
Terminology
Diffuse, benign, vascular lesion of soft tissue affecting large segments of body or multiple tissue planes in contiguous fashion
Clinical Issues
Most present in early childhood
Lower extremities (> 50%)
Benign lesion with frequent recurrences and persistent disease
Macroscopic Features
Predominantly fatty appearance
Microscopic Pathology
Haphazard arrangement of venous-, cavernous-, and capillary-sized vessels
Most common and most characteristic pattern
Diagnostic Checklist
Clinicopathologic diagnosis
 This example of angiomatosis shows a diffuse vascular proliferation involving the upper dermis and extending down into the subcutaneous adipose tissue. |
 A large cavernous vessel with an irregular wall  is surrounded by numerous small to medium-sized capillaries  . |
TERMINOLOGY
Synonyms
Diffuse hemangioma
Vascular malformation
Infiltrating angiolipoma
Definitions
Diffuse, benign, vascular lesion of soft tissue affecting large segments of body or multiple tissue planes in contiguous fashion
ETIOLOGY/PATHOGENESIS
Developmental Anomaly
Likely represents congenital malformation
Thought to arise in early intrauterine life during limb-bud formation
CLINICAL ISSUES
