Clinical Image of AngiokeratomasClinical image demonstrates numerous grouped angiokeratomas in a patient with Anderson-Fabry disease.
Angiokeratoma at Low MagnificationAngiokeratomas are characterized by ectatic vessels in the superficial dermis that appear to herniate into the epidermis. There is often overlying hemorrhage , epidermal acanthosis, and frequently compact hyperkeratosis.
Angiokeratoma With Epidermal Acanthosis and HyperkeratosisThe epidermis overlying angiokeratomas typically demonstrates acanthosis and compact hyperkeratosis . Numerous, dilated, superficial dermal blood vessels are also seen in this field.
Angiokeratoma at High MagnificationThe vessels of angiokeratoma herniate up into the epidermis . The vessels frequently undergo thrombosis, and in this case demonstrates an early thrombus characterized by fibrin admixed with erythrocytes.