Alveolar Soft Part Sarcoma



Alveolar Soft Part Sarcoma


Julie C. Fanburg-Smith, MD

Aaron Auerbach, MD









Hematoxylin & eosin shows a typical example of alveolar soft part sarcoma with an alveolar pattern, mostly seen in older patients. The cells are polygonal and appear to slough into the “alveolar space.”






Hematoxylin & eosin shows alveolar soft part sarcoma with a solid growth pattern separated with thick, fibrous septa. This pattern is common in the tongue and ophthalmic region of younger patients.


TERMINOLOGY


Abbreviations



  • Alveolar soft part sarcoma (ASPS)


Definitions



  • Malignant soft tissue tumor of uncertain phenotype that mainly affects young adults and children


  • Clustering alveolar-like growth pattern, separated by fibrous septa


CLINICAL ISSUES


Presentation



  • Painless mass


  • Intramuscular


  • Hemorrhage


  • Lymphatic invasion


Prognosis



  • Deceptively indolent course


  • Distant metastasis to lung, bone, and brain present in 25%


  • Late recurrence and metastasis common


  • ˜ 60% of patients have distant metastases


  • 5-year survival rate is 65%


MICROSCOPIC PATHOLOGY


Histologic Features

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Alveolar Soft Part Sarcoma
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