2.  The most frequent form of congenital adrenal hyperplasia is due to deficient activity of:

  3.  Which of the following is the most common cause of adrenal hypofunction in the United States?

  4.  Primary pigmented nodular adrenocortical disease (PPNAD) is a form of adrenocortical hyperplasia that is often associated with:

  5.  Surgical excision of an adrenal gland is performed because of a 2-cm well-demarcated tumor. This tumor has a homogeneous, tan-yellow cut surface without hemorrhage or necrosis. Histologically, it is composed of cells with vacuolated cytoplasm in a trabecular arrangement. Large bizarre nuclei are scattered throughout the tumor, but mitotic figures are not appreciated. There is neither vascular nor capsular invasion. The cells are immunoreactive for low molecular weight keratin and vimentin, but not epithelial membrane antigen (EMA). Which of the following is the most likely diagnosis?

  6.  A patient suffering from hypertension undergoes surgical excision of an adrenal tumor. Histologic examination reveals intracytoplasmic eosinophilic inclusions such as the ones seen in this picture. On closer examination, these bodies consist of concentric laminations. The presence of such inclusions indicates:

  7.  Which of the following features is characteristic of adrenocortical carcinoma?

  8.  A large suprarenal mass is removed from a 56-year-old woman. Its histologic appearance is shown in this picture. The tumor displays diffuse immunoreactivity for vimentin, inhibin, calretinin, melan-A, and D2-40. It is negative for S100, EMA, AFP, synaptophysin, chromogranin, and pankeratin. Which of the following is the most likely diagnosis?

  9.  A surgically resected adrenal gland has a circumscribed, but nonencapsulated, tumor measuring 5 cm in greatest dimension. The cut surface is yellow with areas of brown color. The tumor has the microscopic features shown in this picture. Which of the following is the most likely diagnosis?