Organized deposits Non-organized deposits Type-1 cryoglobulinemic GN Light and heavy chain deposition disease (LHCDD) Immunotactoid GN Proliferative GN with monoclonal Ig deposits(PGNMID) Light and heavy chain amyloidosis (Fibrillary GN) Nonproliferative…
Age and sex at dx Interval from symptoms to dx How long did it take to type it Initial symptoms What bx was diagnostic, how many? What was your life…
© Springer International Publishing Switzerland 2015Maria M. Picken, Guillermo A. Herrera and Ahmet Dogan (eds.)Amyloid and Related DisordersCurrent Clinical Pathology10.1007/978-3-319-19294-9_39 39. Medicolegal Issues of Amyloidosis Timothy Craig Allen1 (1) Department of Pathology, The University of Texas Medical Branch,…
Anti-TNF medication Type Administered Diseases treated AA amyloidosis treatment Infection risk Use with caution in patients with Monitoring Antibody, autoimmune associations Etanercept Soluble p75 TNFR:Fc fusion protein Subcutaneous RA AS…
Drug Toxicity Melphalan (Alkeran) (oral) Bone marrow suppression Myelodysplastic syndrome Melphalan (IV with stem-cell rescue) Bone marrow suppression Infection Bortezomib (Velcade) Neuropathy Lenalidomide (Revlimid) Thrombocytopenia GI dysmotility Deep venous thrombosis…
Fig. 2.1 Mechanisms of amyloid formation and toxicity. Intrinsic instability, increased concentration, mutations, proteolytic cleavage or a combination thereof can favour the conversion of the amyloidogenic precursor into its misfolded…
Fig. 4.1 Kidney and liver ALECT2 amyloidosis. Eosinophilic amyloid deposits in the kidney with glomerular, interstitial, and vascular involvement (a, H&E) stain with Congo red (b). Congo red stain viewed…
Fibril protein Precursor protein Systemic and/or localized Acquired or hereditary Target organs AL Immunoglobulin light chain S, L A, He All organs except CNS (Local AL amyloidosis may occur) AH…
CHAPTER 12 Approach to Various Skin Lesions John L. Pfenninger This chapter provides guidelines for the diagnosis and treatment of common skin lesions. Table 12-1 can be used as a…
CHAPTER 192 Joint and Soft Tissue Aspiration and Injection (Arthrocentesis) Thad J. Barkdull, Francis G. O’Connor, John M. McShane Joint and soft tissue aspiration and injection are both clinically rewarding…
