Basicmedical Key

General References Garraway LA, Lander ES. Lessons from the cancer genome. Cell. 2013;153:17–37. International Agency for Research on Cancer (IARC), World Health Organization.  www.cruk.org/cancerstats; 2014. Schneider L. Counseling about cancer….

Cancer and the Environment Although the theme of this chapter emphasizes the genetic basis of cancer, there is no contradiction in considering the role of environment in carcinogenesis. By environment,…

Cytogenetic Changes in Cancer Aneuploidy and Aneusomy As introduced in Chapter 5, cytogenetic changes are hallmarks of cancer, whether sporadic or familial, particularly in later and more malignant or invasive…

Figure 15-10 Standardized incidence ratios (SIRs) for cancers at various sites in first-degree relatives (child or sibling) of an affected person. A SIR is similar to the relative risk ratio (λr) that…

Figure 15-1 General scheme for development of a carcinoma in an epithelial tissue such as colonic epithelium. The diagram shows progression from normal epithelium to local proliferation, invasion across the lamina propria,…

References Specific to Particular Topics Acimovic I, Vilotic A, Pesl M, et al. Human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools. Biomed Res Int. 2014;2014:512831. Ross CA, Akimov…

General References Carlson BM. Human embryology and developmental biology. ed 5. WB Saunders: Philadelphia; 2014. Dye FJ. Dictionary of developmental biology and embryology. ed 2. Wiley-Blackwell: New York; 2012. Epstein…

Concluding Comments Many other examples of this phenomenon could be cited, but the key points to emphasize are that genes are the primary regulators of developmental processes, their protein products…

Genes and Environment in Development Developmental Genetics Development results from the action of genes interacting with cellular and environmental cues. The gene products involved include transcriptional regulators, diffusible factors that…