Basicmedical Key

Metastatic Melanoma Esther Oliva, MD Key Facts Clinical Issues History of melanoma may be remote Macroscopic Features Bilateral or unilateral and multinodular Black cut surface due to pigment content Microscopic…

Melanoma Esther Oliva, MD Key Facts Clinical Issues Age range: 20-50 years Macroscopic Features Black cut surface (occasionally) Microscopic Pathology Diffuse, nested, pseudopapillary (rare) growth Follicle-like spaces may be seen…

Primitive Neuroectodermal Tumor, Ovary Esther Oliva, MD Key Facts Terminology cPNET: Monodermal teratoma composed of tissues closely resembling central nervous system neoplasms with variable degrees of differentiation pPNET: Malignant small…

Immature Teratoma Esther Oliva, MD Key Facts Terminology Malignant germ cell tumor composed of immature tissue derived from the 3 germ layers with variable admixture of mature tissues Clinical Issues…

High-Grade Serous Adenocarcinoma Martin Köbel, MD Blake C. Gilks, MD, FRCPC Key Facts Clinical Issues Bilateral (60%) Mean: 6th to 7th decade Stage dependent; 30-40% overall 5-year survival Macroscopic Features…

Low-Grade Serous Adenocarcinoma Martin Köbel, MD Esther Oliva, MD Key Facts Etiology/Pathogenesis Association with serous borderline tumor KRAS, BRAF, NRAS mutations (MAPK pathway alterations) Clinical Issues Usually high stage Low…

Endocervical Glandular Hyperplasia (Diffuse and Lobular) Marisa R. Nucci, MD Key Facts Clinical Issues Typically incidental finding Excellent prognosis If atypical features present in LEGH, may be associated with adenoma…

Tunnel Clusters Brooke E. Howitt, MD Marisa R. Nucci, MD Key Facts Clinical Issues 8% of all adult women Typically asymptomatic Incidental finding at hysterectomy or cone biopsy Benign Microscopic…

Arias-Stella Reaction Marisa R. Nucci, MD Key Facts Terminology Altered cellular and nuclear change of epithelium most commonly associated with pregnancy Clinical Issues May occur anywhere in female genital tract…

Malignant Melanoma, Vagina C. Blake Gilks, MD, FRCPC Key Facts Clinical Issues < 3% of malignant tumors of vagina Peri- and postmenopausal ages (mean: 57 years) Distal 1/3 (anterior) of…