Antibody Index Antibodies Discussed Antibody Name/Symbol Antibody Description Clones/Alternative Names α-1-antitrypsin alpha-1-antitrypsin A1AT α-fetoprotein alpha 1 fetoprotein AFP, Z5A06, clone C3 β-catenin beta catenin; involved in regulation of cell adhesion…
Ampulla of Vater Cancer Protocol Laura Webb Lamps, MD Ampulla of Vater: Ampullectomy, Pancreaticoduodenectomy (Whipple Resection) Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Ampulla of…
Paraganglioma Mari Mino-Kenudson, MD Key Facts Terminology Gangliocytic paraganglioma Uncommon (approximately 1% of ampullary neoplasms) Some cases associated with NF-1 Clinical Issues Most commonly involve periampullary duodenum Clinically benign Microscopic…
Poorly Differentiated Neuroendocrine Carcinoma, Ampulla Vikram Dishpande, MD Key Facts Clinical Issues Aggressive tumors with mean survival of 14.5 months Microscopic Pathology Tumors resemble either small cell carcinoma or large…
Ampullary Adenocarcinoma and Variants Mari Mino-Kenudson, MD Key Facts Terminology Ampullary adenocarcinoma comprises both adenocarcinomas arising in ampullary region and periampullary duodenal adenocarcinomas Clinical Issues 5-year survival rate after surgical…
Well-differentiated Neuroendocrine Neoplasm, Ampulla Vikram Deshpande, MD Key Facts Etiology/Pathogenesis Syndromic cases associated with neurofibromatosis, MEN1, Zollinger-Ellison syndrome Clinical Issues Behavior/prognosis difficult to predict Size, mitotic rate are poor predictors…
Ampullary Adenoma Mari Mino-Kenudson, MD Key Facts Clinical Issues Most are sporadic Seen in 50-95% of patients with (FAP) and Gardner syndrome Macroscopic Features May involve one or more parts…
Exocrine Pancreas Cancer Protocol Laura Webb Lamps, MD Pancreas (Exocrine): Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Head of pancreas ____ Body of pancreas…
Endocrine Pancreas Cancer Protocol Laura Webb Lamps, MD Pancreas (Endocrine): Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen ____ Head of pancreas ____ Body of pancreas ____ Tail of pancreas…
Well-differentiated Neuroendocrine Neoplasm, Pancreas Vikram Deshpande, MD Key Facts Etiology/Pathogenesis MEN1 von Hippel-Lindau syndrome Tuberous sclerosis Sporadic Clinical Issues Surgical resection remains mainstay of therapy for tumors confined to pancreas…
