Cisplatin Nephrotoxicity Shane M. Meehan, MBBCh Key Facts Terminology Nephropathy due to direct toxicity of platinum compounds Etiology/Pathogenesis Cis-diachlorodiammineplatinum II is heavy metal and potent inhibitor of DNA synthesis Clinical…
Hepatorenal Syndrome/Bile Nephrosis Anthony Chang, MD Key Facts Etiology/Pathogenesis Elevated blood bilirubin leads to intratubular bile casts Direct toxicity to tubular epithelial cells by bilirubin and bile salts and subsequent…
Renal Artery Stenosis A. Brad Farris, III, MD Key Facts Etiology/Pathogenesis Renal artery stenosis from variety of potential causes results in ischemic atrophy Atherosclerosis with atheromatous plaques is one of…
Thrombotic Microangiopathy, Drugs Neeraja Kambham, MD Key Facts Etiology/Pathogenesis Direct endothelial injury or immune mediated > 60 drugs reportedly associated with TMA, but often difficult to establish causative role Chemotherapeutic…
Giant Cell Arteritis Surya V. Seshan, MD Key Facts Terminology Granulomatous arteritis of aorta and its major branches Etiology/Pathogenesis Possible triggers include exposure to several upper respiratory disease pathogens Associated…
Granulomatosis with Polyangiitis (Wegener) Surya V. Seshan, MD Key Facts Etiology/Pathogenesis Form of ANCA-mediated small vessel vasculitis Usually due to anti-PR3 antibodies (˜ 75%), others to MPO Clinical Issues Peak…
Churg-Strauss Syndrome Surya V. Seshan, MD Key Facts Terminology Synonyms: Allergic granulomatosis and angiitis Etiology/Pathogenesis Triggers: Allergens, vaccines, drugs T-helper cell and eosinophil activation Clinical Issues Occurs in any age,…
Overview and Classification of Systemic Vasculitides Surya V. Seshan, MD This schematic shows the predominant range of vascular involvement by different vasculitides, as described in the Chapel Hill Consensus Conference…
Diffuse Mesangial Sclerosis Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Terminology Diffuse mesangial sclerosis Etiology/Pathogenesis WT1 mutations (Denys-Drash or Frasier syndromes) Laminin β2 mutations (Pierson syndrome) Idiopathic Clinical…
Monoclonal Immunoglobulin Deposition Disease Lynn D. Cornell, MD Key Facts Clinical Issues Nephrotic syndrome Acute or chronic renal failure Multiple myeloma diagnosable in ˜ 40% of patients with pure MIDD…
