Sarcoid Lymphadenopathy Sa A. Wang, MD Key Facts Terminology Multisystemic chronic granulomatous disease Etiology/Pathogenesis Unknown Clinical Issues Multisystem involvement Therapy may not be required if asymptomatic Prognosis depends on involvement…
Protocol for Examination of Hodgkin Lymphoma Specimens L. Jeffrey Medeiros, MD Hodgkin Lymphoma: Biopsy, Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Lymph node(s) ____…
Rosai-Dorfman Disease Faisal Alseraye, MD L. Jeffrey Medeiros, MD Key Facts Terminology Rosai-Dorfman disease (RDD) and sinus histiocytosis with massive lymphadenopathy are equivalent terms Etiology/Pathogenesis Unknown; histologic features are suggestive…
Progressive Transformation of Germinal Centers Pei Lin, MD Key Facts Terminology Progressive transformation of germinal centers (PTGC) Clinical Issues Young adults most commonly affected Asymptomatic localized lymphadenopathy in most patients…
Human Immunodeficiency Virus Lymphadenitis Tariq Muzzafar, MBBS Key Facts Terminology Human immunodeficiency virus (HIV) Lymphadenitis caused by HIV infection Clinical Issues History of high-risk exposure should be sought Microscopic Pathology…
Inflammatory Pseudotumor Francisco Vega, MD, PhD Key Facts Terminology Inflammatory reaction with multifactorial pathogenesis Infectious etiologies account for subset of cases Clinical Issues Young adults with fever and constitutional symptoms…
Coccidioides Lymphadenitis Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis 2 species: C. immitis prevalent in California, USA; C. posadasii in other regions Clinical Issues May be seen in nonendemic areas Travel…
Cytomegalovirus Lymphadenitis Sa A. Wang, MD Key Facts Terminology Lymphadenitis caused by cytomegalovirus (CMV) infection Etiology/Pathogenesis Member of β-herpes viruses Causes cytopathic changes Lytic infection: Immediate-early, early, and late viral…
Toxoplasma Lymphadenitis Carlos E. Bueso-Ramos, MD, PhD Key Facts Etiology/Pathogenesis Toxoplasma gondii is parasitic protozoan Cat is definitive host for sexual stage of reproduction Oocysts containing trophozoites are generated that…
Cryptococcal Lymphadenitis Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis Infection by Cryptococcus neoformans Most cases are associated with immunosuppression > 80% of cases associated with AIDS Microscopic Pathology Cryptococcus neoformans Single…
