Protocol for Specimens of Malignant Melanoma of the Skin David Cassarino, MD, PhD Melanoma of the Skin Biopsy, Excision, Reexcision Procedure (select all that apply) ____ Biopsy, shave ____ Biopsy,…
Other Unusual and Rare Variants of Melanoma David Cassarino, MD, PhD Key Facts Terminology Rare variants of melanoma including chondroid and osseous melanoma, myxoid melanoma, rhabdoid melanoma, and balloon cell…
Sinonasal Melanoma Lester D. R. Thompson, MD Key Facts Terminology Neural crest-derived neoplasms originating from melanocytes and demonstrating melanocytic differentiation Clinical Issues Anterior nasal septum > maxillary sinus Overall prognosis…
Desmoplastic Melanoma Soheil Sam Dadras, MD, PhD Olubukola Babalola David Cassarino, MD, PhD Key Facts Terminology Invasive melanoma that often resembles an inflamed scar Clinical Issues Firm skin-colored, tan or…
Pigmented Epithelioid Melanocytoma (“Animal-type Melanoma”) Soheil Sam Dadras, MD, PhD Olubukola Babalola Key Facts Clinical Issues Heavily pigmented, dome-shaped nodule Occur sporadically or in association with Carney complex Low-grade malignant…
Molecular Factors Index Molecular Factors Discussed Molecular Factor Chromosomal Location Definition/Alternative Names Chapters β-catenin (see CTNNB1) 10p, loss of 10p Childhood Melanoma 10q, loss of 10q Childhood Melanoma; Perineurioma 11p,…
Melanoma, Superficial Spreading Type Soheil Sam Dadras, MD, PhD Nicole Carreau Key Facts Terminology Most common variant of invasive melanoma Clinical Issues Most frequently occurs on back for males, legs…
Antibody Index Antibodies Discussed Antibody Name/Symbol Antibody Description Clones/Alternative Names Chapters α1-antichymotrypsin alpha 1 antichromotrypsin A1ACT Myofibroma and Myofibromatosis; PEComas α-fetoprotein alpha 1 fetoprotein AFP, Z5A06, Clone C3 Metastatic Tumors…
Oral Melanoma Lester D. R. Thompson, MD Key Facts Terminology Malignant neural crest-derived neoplasm with melanocytic differentiation Clinical Issues Extremely rare, accounting for < 1% of all melanomas Represent <…
Primary Dermal Melanoma David Cassarino, MD, PhD Key Facts Terminology Primary cutaneous melanoma arising in dermis or subcutis, mimicking metastatic melanoma By definition, lacks any evidence of epidermal involvement, ulceration,…
