Overview of Lipoblasts and Mimics
Overview of Lipoblasts and Mimics David R. Lucas, MD Lipoblasts come in a variety of sizes and shapes. The cytoplasm is filled with lipid that appears as 1 or multiple…
Soft Tissue Immunohistochemistry
Soft Tissue Immunohistochemistry Cyril Fisher, MD, DSc, FRCPath Immunohistochemistry of Selected Spindle Cell Soft Tissue Tumors Tumor CD34 CK SMA S100 Desmin Other Diagnostic Markers Angiosarcoma + ± – –…
Overview of Grading and Staging
Overview of Grading and Staging Cyril Fisher, MD, DSc, FRCPath This is leiomyosarcoma with a differentiation score of 1. The tumor is composed of well-organized fascicles of spindle cells with…
Translocations and Other Genetic Anomalies in Sarcomas
Translocations and Other Genetic Anomalies in Sarcomas Cyril Fisher, MD, DSc, FRCPath Diagnostic Molecular and Cytogenetic Findings in Sarcomas Histologic Type Translocation or Rearrangement Fusion Gene or Other Feature Alveolar…
Molecular Factors Index
Molecular Factors Index Molecular Factors Discussed Molecular Factor Chromosomal Location Definition/Alternative Names Chapters β-catenin 3p21 catenin (cadherin-associated protein), beta 1; beta-catenin; CTNNB1 Adrenal Cortical Adenoma; Adrenal Cortical Carcinoma; Calcifying Fibrous…
Antibody Index
Antibody Index Antibodies Discussed Antibody Name/Symbol Antibody Description Clones/Alternative Names Chapters α-1-antichymotrypsin alpha 1 antichromotrypsin Calcifying Fibrous Tumor α-1-antitrypsin alpha 1 antitrypsin A1AT Yolk Sac Tumor α-fetoprotein alpha 1 fetoprotein…
Glioblastoma
Glioblastoma Alexandros D. Polydorides, MD, PhD Key Facts Terminology Highly malignant (grade IV) astrocytic neoplasm Etiology/Pathogenesis Secondary GBM: From lower grade astrocytoma In 4-5 years; women, children; TP53 mutation Primary…
Protocol for Brain/Spinal Cord Tumor Specimens
Protocol for Brain/Spinal Cord Tumor Specimens Brain/Spinal Cord Biopsy/Resection *History of Previous Tumor/Familial Syndrome *____ None known *____ Known (specify, if known: ______________________________) *____ Not specified Specimen Type/Procedure ____ Open…
Oligodendroglioma
Oligodendroglioma Alexandros D. Polydorides, MD, PhD Key Facts Clinical Issues 2-5% of all primary brain tumors, 5-25% of gliomas Most occur in adults, 5-7% arise in infancy/childhood 90% in supratentorial…
Simple Bone Cyst
Simple Bone Cyst Jessica M. Comstock, MD Key Facts Terminology Unicameral bone cyst Solitary bone cyst Benign, solitary cyst in metaphysis of long bones Clinical Issues 1st and 2nd decades…
