Soft Tissue Immunohistochemistry



Soft Tissue Immunohistochemistry


Cyril Fisher, MD, DSc, FRCPath

















































































































Immunohistochemistry of Selected Spindle Cell Soft Tissue Tumors


Tumor


CD34


CK


SMA


S100


Desmin


Other Diagnostic Markers


Angiosarcoma


+


±





CD31, FLI-1, FVIIIRAg


Dermatofibrosarcoma


+




+ (Bednar)




Follicular dendritic cell sarcoma





+



CD21, CD23, CD35, fascin, D2-40


Gastrointestinal stromal tumor


+



+



±


CD117, DOG1, H-caldesmon


Inflammatory myofibroblastic tumor



±


+



±


ALK (50%)


Kaposi sarcoma


+






CD31, HHV8


Leiomyosarcoma



±


±



+


H-caldesmon, SMM


Myofibrosarcoma




+



±


Calponin, H-caldesmon (-)


Malignant peripheral nerve sheath tumor


±


±



±


+ (Triton)



Solitary fibrous tumor


+






Bcl-2, CD99, CD56


Spindle cell carcinoma



+


+




EMA, CK5/6, CK34βE12


Synovial sarcoma



+



±



EMA, TLE1, CD99, CD56


± = Positive in some cases.










































































































Immunohistochemistry of Selected Epithelioid Cell Soft Tissue Tumors


Antibody


Epithelioid Sarcoma


Epithelioid MPNST


Epithelioid Angiosarcoma


Anaplastic Large Cell Lymphoma


Carcinoma


Melanoma


CK-PAN


+



+


*


+


*


EMA


+


*


*


+


+



S100



+




±


+


CD34


±



±





CD31




+





Desmin







*


SMA


+







INI1



±


+


+


+


+


p63






+



CD30



*



+




CD45





+




* * Rarely positive. MPNST = malignant peripheral nerve sheath tumor.



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Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Soft Tissue Immunohistochemistry
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