Mixed Liposarcoma
Thomas Mentzel, MD
Key Facts
Terminology
Liposarcoma showing morphologic/genetic features of combined myxoid liposarcoma and atypical lipomatous tumor/dedifferentiated liposarcoma, or of myxoid liposarcoma and pleomorphic liposarcoma
Clinical Issues
Extremely rare
Microscopic Pathology
Abrupt or irregular admixture of different liposarcoma components
Combination of atypical lipomatous tumor/dedifferentiated liposarcoma and myxoid liposarcoma
Combination of myxoid liposarcoma and pleomorphic liposarcoma
 Hematoxylin & eosin shows low-power view of a biphasic lipogenic neoplasm. On the left, features of low-grade myxoid liposarcoma are seen; atypical lipomatous tumor is present on the right. |
 Small undifferentiated cells and univacuolated lipoblasts are set in a prominent myxoid stroma with numerous thin-walled and branching vessels  in the myxoid liposarcoma component. |
TERMINOLOGY
Definitions
Liposarcoma showing morphologic/genetic features of combined myxoid liposarcoma and atypical lipomatous tumor/dedifferentiated liposarcoma, or of myxoid liposarcoma and pleomorphic liposarcoma
CLINICAL ISSUES
Epidemiology
Incidence
Extremely rare
Age
Elderly patients
Site
Extremities
Retroperitoneum
Intraabdominal sites
Mediastinum
Presentation
Painless mass
Slow growing
Natural History
May show long preoperative duration
Increased rate of recurrences
Metastases may occur
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