Antihypertensives

 evolve.elsevier.com/McCuistion/pharmacology/



Hypertension


Hypertension is an increase in blood pressure such that the systolic pressure is greater than 140 mm Hg and the diastolic pressure is greater than 90 mm Hg. Essential hypertension is the most common type, affecting 90% of persons with high blood pressure. The exact origin of essential hypertension is unknown; however, contributing factors may include hyperlipidemia, African American race, diabetes, aging, stress, excessive alcohol ingestion, smoking, obesity, and a family history of hypertension. Ten percent of hypertension cases are related to renal and endocrine disorders and are classified as secondary hypertension. Hypertension is the most common condition leading to myocardial infarction (MI), stroke, renal failure, and death.

Selected Regulators of Blood Pressure


The kidneys and blood vessels strive to regulate and maintain a “normal” blood pressure. The kidneys regulate blood pressure by control of fluid volume and via the renin-angiotensin-aldosterone system (RAAS; Fig. 39.1). Kidneys control sodium and water elimination and retention, which affects cardiac output and systemic arterial blood pressure. Renin from the renal cells stimulates production of angiotensin II, a potent vasoconstrictor that causes the release of aldosterone, an adrenal hormone that promotes sodium retention and thereby water retention. Retention of sodium and water causes fluid volume to increase, elevating blood pressure.

The baroreceptors in the aorta and carotid sinus and the vasomotor center in the medulla also assist in the regulation of blood pressure. Catecholamines such as norepinephrine, released from the sympathetic nerve terminals, and epinephrine, released from the adrenal medulla, increase blood pressure through vasoconstrictive activity.

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FIG. 39.1 The renin-angiotensin-aldosterone system (RAAS). Renin, an enzyme located in the juxtaglomerular cells of the kidney, is released when blood pressure decreases. This diagram shows how the RAAS restores fluid balance and stabilizes blood pressure.

Other hormones that contribute to blood pressure regulation are antidiuretic hormone (ADH), atrial natriuretic peptide (ANP) hormone, and brain natriuretic peptide (BNP) hormone. ADH is produced by the hypothalamus and is stored and released by the posterior pituitary gland (neurohypophysis). This hormone stimulates the kidneys to conserve and retain water when there is a fluid volume deficit. When there is fluid overload, ADH secretion is inhibited, and the kidneys then excrete more water.

Physiologic Risk Factors


Certain physiologic risk factors contribute to hypertension. A diet high in saturated fat and simple carbohydrates can increase blood pressure. Carbohydrate intake can affect sympathetic nervous activity. Alcohol increases renin secretions, causing the production of angiotensin II. Obesity affects the sympathetic and cardiovascular systems by increasing cardiac output, stroke volume, and left ventricular filling. Two thirds of hypertensive persons are obese. Normally weight loss can decrease hypertension, as can mild to moderate sodium restriction.

Cultural Responses to Antihypertensive Agents


African Americans are more likely to develop hypertension at an earlier age than Caucasians. African Americans also have a higher mortality rate from hypertension than the Caucasian population. The use of beta-adrenergic blockers (beta blockers) and angiotensin-converting enzyme (ACE) inhibitors is less effective for the control of hypertension in African Americans unless the drug is combined or given with a diuretic. This group is susceptible to low-renin hypertension, therefore they do not respond well to beta blockers and ACE inhibitors. The antihypertensive drugs that are effective for African Americans are alpha1 blockers and calcium channel blockers (calcium blockers). African American patients do respond to diuretics as the initial monotherapy for controlling hypertension. Caucasian patients usually have high-renin hypertension and respond well to all antihypertensive agents.

Asian Americans are twice as sensitive as Caucasians to beta blockers and other antihypertensives. A reduction in antihypertensive dosing is frequently needed. Native Americans have a reduced or lower response to beta blockers compared with Caucasians. Monitoring blood pressure and drug dosing should be an ongoing assessment for patients in these cultural groups.

Hypertension in Older Adults


Approximately 70 million American adults have hypertension, which is 29% of the adult population, about one in three people. Only approximately 52% of hypertensive individuals have this condition under control. Of individuals over 60 years of age, 65% have developed hypertension. Typically, in the age range of 18 to 49, males have more prevalence of hypertension than females. By age 70, the prevalence of hypertension in Caucasian males is 50%, whereas the female prevalence is 55%. Both systolic and diastolic hypertension are associated with increased cardiovascular morbidity and mortality. With antihypertensive therapy, the greatest decrease in cardiovascular disorders is 34% for stroke and 19% for coronary heart disease.

One of the troublesome side effects of the use of antihypertensive agents in older adults, especially frail or institutionalized persons, is orthostatic (postural) hypotension. This episode of sudden low blood pressure presents as dizziness due to blood pooling in the lower extremities when an individual changes to an upright position. In older adults, the sympathetic nervous system does not respond as quickly to correct the situation, especially when potentiated by antihypertensive drug administration. If orthostatic hypotension occurs, the antihypertensive drug dose may need to be decreased or another antihypertensive drug may need to be used. Older adults with hypertension should be instructed to modify their lifestyle and activities. This includes restricting dietary sodium to 2400 mg daily, avoiding tobacco, modifying diet, exercising, and decreasing stress.

Nonpharmacologic Control of Hypertension


A sufficient decrease in blood pressure can be accomplished by nonpharmacologic methods. There are many nonpharmacologic ways to decrease blood pressure, but if the systolic pressure is greater than 140 mm Hg, antihypertensive drugs are generally ordered. Nondrug methods to decrease blood pressure include stress-reduction techniques, exercise, salt restriction, decreased alcohol ingestion, and smoking cessation.

When hypertension cannot be controlled by nonpharmacologic means, antihypertensive drugs are prescribed. However, nonpharmacologic methods should be combined with antihypertensive drugs to control hypertension.

Guidelines for Hypertension


Blood pressure guidelines for determining hypertension have been revised and are contained in the Eighth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, or JNC 8, from 2014. The purpose of these guidelines is to decrease the risk of cardiovascular disease (CVD) in the American population. The guideline for normal blood pressure is less than 120/80 mm Hg. Prehypertension is defined as systolic blood pressure (SBP) of 120 to 139 and diastolic blood pressure (DBP) of 80 to 89. Stage 1 hypertension falls between 140/90 and 159/99, and stage 2 hypertension is 160/100 or greater.

Two out of three patients with hypertension have uncontrolled blood pressure or are not optimally treated. SBP is more important than DBP as a CVD risk. According to the JNC 8, a blood pressure of 140/90 is the goal for the population younger than 60 years, with a target of 150/90 for those above 60.

Pharmacologic Control of Hypertension


An individualized approach to the treatment of hypertension is used by many health care providers. All drugs are considered initial agents when first prescribed for hypertension. Reduction of other cardiovascular risk factors and the use of fewer drugs (i.e., substituting instead of adding drugs) at the lowest effective doses are emphasized. Often more than one antihypertensive is used to control blood pressure, which also may lead to fewer adverse effects.

Antihypertensive drugs, used either singly or in combination with other drugs, are classified into six categories: (1) diuretics, (2) sympatholytics (sympathetic depressants), (3) direct-acting arteriolar vasodilators, (4) ACE inhibitors, (5) angiotensin II–receptor blockers (ARBs), and (6) calcium channel blockers.

Diuretics


Diuretics promote sodium depletion, which decreases extracellular fluid volume (ECFV). Diuretics are effective as first-line drugs for treating mild hypertension. Hydrochlorothiazide is the most frequently prescribed diuretic for controlling mild hypertension by decreasing excess fluid volume. It can be used alone for recently diagnosed or mild hypertension, or it can be used with other antihypertensive drugs. Many antihypertensive drugs can cause fluid retention; therefore diuretics are often administered together with antihypertensive agents. The various types of diuretics are discussed in Chapter 38.

Thiazide diuretics are not recommended for patients with renal insufficiency (creatinine clearance <30 mL/min). The loop (high-ceiling) diuretics such as furosemide are usually recommended because they do not depress renal blood flow. Loop diuretics are not used if hypertension is the result of RAAS involvement because they tend to elevate serum renin level immediately. Instead of a single thiazide drug, a combination of potassium-wasting and potassium-sparing diuretics may be useful; less potassium excretion would occur. In addition, thiazides can be combined with other antihypertensive drugs to increase their effectiveness. Box 39.1 lists the combinations of thiazides with other drugs. Many drug products on the market include combinations of thiazide diuretics and potassium-sparing diuretics, beta blockers, ACE inhibitors, or ARBs. ACE inhibitors tend to increase serum potassium (K) levels, so when they are combined with a thiazide diuretic, serum potassium loss is minimized.

Sympatholytics (Sympathetic Depressants)


The sympatholytics comprise five groups of drugs: (1) beta-adrenergic blockers, (2) centrally acting alpha2 agonists, (3) alpha-adrenergic blockers, (4) adrenergic neuron blockers (peripherally acting sympatholytics), and (5) alpha1– and beta1-adrenergic blockers. Beta-adrenergic blockers block the beta receptors, and alpha-adrenergic blockers block the alpha receptors.

icon Beta-Adrenergic Blockers


Beta-adrenergic blockers, frequently called beta blockers, are used as antihypertensive drugs or in combination with a diuretic. Beta blockers are also used as antianginals and antidysrhythmics and are discussed in this context in Chapter 37.

Beta (β+ and β)-adrenergic blockers reduce cardiac output by diminishing the sympathetic nervous system response to decrease basal sympathetic tone. With continued use of beta blockers, vascular resistance is diminished, and blood pressure is lowered. Beta blockers reduce heart rate, contractility, and renin release. The hypotensive response is greater in patients with higher renin levels.

African American hypertensive patients do not respond well to beta blockers alone for the control of hypertension. Instead, hypertension in the African American population can be controlled by combining beta blockers with diuretics.

There are many types of beta blockers. Nonselective beta blockers, such as propranolol and carvedilol, inhibit beta1 (heart) and beta2 (bronchial) receptors. Heart rate slows, blood pressure decreases secondary to the decrease in heart rate, and bronchoconstriction occurs because of unopposed parasympathetic tone. Cardioselective beta blockers are preferred because they act mainly on the beta1—rather than the beta2—receptors and bronchoconstriction is less likely to occur. Acebutolol, atenolol, betaxolol, bisoprolol, and metoprolol are cardioselective beta blockers that block beta1 receptors.

 


BOX 39.1Combination of Thiazides With Antihypertensive Drugs and Other Combinations

Thiazide With Potassium-Sparing Diuretics


• Hydrochlorothiazide with spironolactone


• Hydrochlorothiazide with amiloride


• Hydrochlorothiazide with triamterene

Thiazide With Beta Blockers


• Hydrochlorothiazide with bisoprolol fumarate


• Hydrochlorothiazide with metoprolol


• Bendroflumethiazide with nadolol

Tenoretic


• Chlorthalidone (thiazide-like diuretic) with atenolol

Thiazide With Angiotensin-Converting Enzyme Inhibitors


• Hydrochlorothiazide with benazepril


• Hydrochlorothiazide with captopril


• Hydrochlorothiazide with enalapril maleate


• Hydrochlorothiazide with fosinopril


• Hydrochlorothiazide with lisinopril


• Hydrochlorothiazide with moexipril


• Hydrochlorothiazide with quinapril

Thiazide With Angiotensin II Antagonists


• Hydrochlorothiazide with candesartan


• Hydrochlorothiazide with eprosartan


• Hydrochlorothiazide with irbesartan


• Hydrochlorothiazide with losartan


• Hydrochlorothiazide with olmesartan


• Hydrochlorothiazide with telmisartan


• Hydrochlorothiazide with valsartan

Thiazide With Centrally Acting Alpha2 Agonist


• Chlorthalidone with clonidine


• Hydrochlorothiazide with methyldopa

Combination of Angiotensin-Converting Enzyme Inhibitors With Calcium Channel Blocker


• See Table 39.3.

Combination of Calcium Channel Blocker With Statin Drug


• Amlodipine with atorvastatin

Cardioselectivity does not confer absolute protection from bronchoconstriction. In tests measuring forced expiratory volume in 1 second (FEV1) as a measure of β reactivity, only atenolol demonstrated true protection. Other cardioselective beta blockers were only partially effective. Studies also show that at the upper end of the dosage range, cardioselectivity is less effective. In patients with preexisting bronchospasm or other pulmonary disease, beta blockers—even those considered to be cardioselective—should be used with caution. Some experts regard this as a relative contraindication. The real value of beta selectivity is in maintaining renal blood flow and minimizing the hypoglycemic effects of beta blockade.

The combination of beta blockers with hydrochlorothiazides is packaged together in tablet form (see Box 39.1). Usually the hydrochlorothiazide dose is 12.5 to 25 mg.

Beta blockers tend to be more effective in lowering blood pressure in patients who have an elevated serum renin level. The cardioselective prototype drug metoprolol is presented in Prototype Drug Chart 39.1.

Beta blockers should not be used by patients with second- or third-degree atrioventricular (AV) block or sinus bradycardia. A noncardioselective beta blocker such as propranolol should not be given to a patient with chronic obstructive pulmonary disease (COPD).

Pharmacokinetics


Metoprolol is well absorbed from the gastrointestinal (GI) tract. Its half-life is short, and its protein-binding power is low.

Pharmacodynamics


Cardioselective beta-adrenergic blockers block beta1 receptors, thereby decreasing heart rate and blood pressure. The nonselective beta blockers block beta1 and beta2 receptors, which can result in bronchial constriction. Beta blockers cross the placental barrier and are excreted in breast milk.

The onset of action of oral beta blockers is usually 60 minutes or less, and the duration of action is usually 24 hours with some exceptions. The peak for extended release is usually 1 to 7 hours, and the duration is typically 24 hours. When beta blockers are administered intravenously, the onset of action is immediate, peak time is 20 minutes, and duration of action is approximately 4 to 10 hours.

Side Effects and Adverse Reactions

Side effects and adverse reactions include decreased pulse rate; markedly decreased blood pressure; and with noncardioselective beta1 and beta2 blockers, bronchospasm. Beta blockers should not be abruptly discontinued because rebound hypertension, angina, dysrhythmias, and MI can result. Beta blockers can cause dizziness, insomnia, depression, fatigue, nightmares, and sexual dysfunction. Table 39.1 lists the beta blockers used to treat hypertension and their dosages, uses, and considerations.

Noncardioselective beta blockers inhibit the liver’s ability to convert glycogen to glucose in response to hypoglycemia. Because of this side effect, beta blockers should be used with caution in patients with diabetes mellitus. In addition, bradycardia is a very common adverse effect of beta blockers.

 


icon icon PROTOTYPE DRUG CHART 39.1Metoprolol


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A, Adult; AV, atrioventricular; C, child; COPD, chronic obstructive pulmonary disease; d, day; h, hour; HF, heart failure; maint, maintenance; MAOI, monoamine oxidase inhibitor; max, maximum; min, minute; NSAID, nonsteroidal antiinflammatory drug; PB, protein binding; PO, by mouth; SSRI, selective serotonin reuptake inhibitor; t½, half-life; UK, unknown; y, year.


 Pregnancy categories have been revised. See www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Labeling/ucm093307.htm for more information.



icon TABLE 39.1


Antihypertensives: Beta Blockers and Central Alpha2 Agonists


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A, Adult; AMI, acute myocardial infarction; bid, twice a day; C, child; d, day; GI, gastrointestinal; h, hour; HTN, hypertension; IV, intravenous; maint, maintenance; max, maximum; min, minutes; PB, protein binding; PO, by mouth; PVCs, premature ventricular contractions; q, every; t½, half-life; tid, three times a day.


 Pregnancy categories have been revised. See www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Labeling/ucm093307.htm for more information.


 


icon Nursing Process: Patient-Centered Collaborative Care

icon Antihypertensives: Beta Blockers

Assessment


• Obtain a medication and herbal history from the patient. Report if a drug-drug or drug-herbal interaction is probable.


• Obtain vital signs. Report abnormal blood pressure and bradycardia, and compare vital signs with baseline findings.


• Check laboratory values related to renal and liver function periodically. Elevated blood urea nitrogen (BUN) and serum creatinine may be caused by beta blockers or a cardiac disorder. Elevated cardiac enzymes, such as aspartate transaminase (AST) and lactate dehydrogenase (LDH), may be caused by beta blockers or cardiac disorder.

Nursing Diagnoses


• Cardiac Output, Decreased related to variations in blood pressure readings


• Noncompliance with drug regimen related to cost of multiple drugs ordered


• Sexual Dysfunction related to a side effect of beta blockers


• Knowledge, Deficient related to inexperience with beta blockers

Planning


• The patient’s blood pressure will be decreased or will return to a normal value.


• The patient states he or she will take medication as prescribed.


• The patient will verbalize the importance of following the beta-blocker regimen.

Nursing Interventions


• Monitor vital signs, especially blood pressure and pulse.


• Monitor laboratory results, especially BUN, serum creatinine, AST, and LDH.

Patient Teaching

General


icon Encourage patients to comply with the drug regimen. Advise that abrupt discontinuation of antihypertensive drugs may cause rebound hypertension.


• Inform patients that herbs can interfere with beta blockers (Complementary and Alternative Therapies 39.1).


icon Advise patients to avoid over-the-counter (OTC) drugs without first checking with a health care provider. Many OTC drugs carry warnings against use in presence of hypertension or concurrent use with antihypertensives.

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Apr 8, 2017 | Posted by in PHARMACY | Comments Off on Antihypertensives
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