Well-Differentiated Papillary Mesothelioma



Well-Differentiated Papillary Mesothelioma


Cyril Fisher, MD, DSc, FRCPath









Hematoxylin & eosin shows well-formed branching papillary structures or blunt processes arising from the peritoneal surface.






Hematoxylin & eosin shows papillae covered by a single layer of uniform cuboidal mesothelial cells with rounded central nuclei and eosinophilic cytoplasm. Note collagen fibers in the papillary core.


TERMINOLOGY


Synonyms



  • Benign mesothelioma


  • Mesothelioma of low malignant potential


ETIOLOGY/PATHOGENESIS


Environmental Exposure



  • Some patients have history of asbestos exposure


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Rare



      • Peritoneum, omentum, pleura, pericardium


      • Paratesticular (tunica vaginalis)


  • Age



    • Predominantly 30-50 years


  • Gender



    • Peritoneal lesions mostly in females


    • Pleural lesions M = F


Presentation



  • Incidental finding


Treatment



  • Surgical approaches



    • Excision of localized lesion


  • Adjuvant therapy



    • Chemotherapy for multiple or widespread lesions

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Well-Differentiated Papillary Mesothelioma
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