Fanconi anemia |
DNA repair defect (autosomal/X-linked recessive) with increased incidence of AML Aplastic anemia in >90%, prominent neonatal cytopenia, pancytopenia by midchildhood Gradual development of single and multilineage aplasia Associated congenital anomalies of bone, skin, kidney; mental retardation |
15 genes (A-P) identified—most common: |
FANCA (16q24.3; exon 43) 60%-70% |
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FANCC (9q22.3; exon 14) ˜14% |
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FANCG (9p13; exon 14) ˜10% |
Dyskeratosis congenita |
DNA repair defect, unable to maintain telomere complex (uncharacterized genetic subtype in 50%) Gradual development of pancytopenia and aplastic anemia (˜80%) Initial hypercellularity common Associated with congenital anomalies of skin, nails, mucosa; frequent mental retardation |
Four genes identified: |
X-linked recessive (˜30%) |
DKC1/dyskerin (Xq28; exon 15) |
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Autosomal dominant (10%) |
TERC (3q26; exon1) |
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TERT (5p15; exon16) |
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Autosomal recessive (˜1%) |
NOP10 (15q14; exon 2) |
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TERT (5p15; exon 16) |
Diamond-Blackfan anemiaa |
90% cases are sporadic. Inherited forms are <10%, due to autosomal inheritance and haplodeficiency. Likely intrinsic progenitor cell defect Constitutional red cell aplasia (rare erythroblasts present) Some patients develop marrow failure. |
Associated with congenital anomalies, especially skeletal (30%-40%) |
Nine genes identified: (RPS19, RPL5, RPL11, RPL35A, RPS24, RPS17, RPS7, RPS10, and RPS26) 50%-60% cases carry at least one of these mutants. |
Autosomal dominant |
RPS19 (19q13.2), 25%, 129 distinct mutations |
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RPL5 (1p22.1), 6.6%, 39 mutations |
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RPS10 (6p21.31), 6.4%, 3 mutations |
Congenital dyserythropoietic/idiopathic aplastic anemiaa |
Erythroid hyperplasia/aplasia |
Associated with distinctive bone marrow abnormalities including multinucleation, nuclear bridging, and megaloblastic changes/bone marrow failure |
Chromosomal instability and increased incidence of malignancy (repair defect) |
Heterozygous mutations in TERC and TERT are risk factors for some cases. |
Shwachman-Diamond syndromeb |
Constitutional neutropenia with frequent development of aplasia (˜20%) |
Associated with congenital anomalies including exocrine pancreas insufficiency |
One gene identified: |
Autosomal recessive (˜90%) |
SBDS (7q11; exon 5) |
Thrombocytopenia with absent radiic (TAR) |
Constitutional thrombocytopenic disorder with reduced megakaryocytes and bone anomalies |
Compound inheritance (biallelic) of a low-frequency noncoding SNP and a rare null mutation in RBM8A (55) |
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RBM8A (1q21) |
Congenital amegakaryocytic thrombocytopeniac |
Isolated thrombocytopenia with decreased/no megakaryocytes |
50% patients develop aplastic anemia at the age of 5. |
Can evolve into MDS |
Genetically heterogeneous; one autosomal recessive subtype characterized |
C-MPL (1p34.2) |
Lysosomal enzyme defects/storage disorders (multiple types): |
Over 40 genetic disorders (˜1 in 7000 live births) with mostly secondary hematologic manifestations |
Accumulation of substrate protein within histiocytes/macrophages |
Increased bone marrow histiocytes with distinctive morphology |
Classification into six groups: |
Lipid storage disorders (Gaucher, Niemann-Pick) Gangliosidosis (Tay-Sachs disease) Leukodystrophies (ADL, MLD, Krabbe, Refsum, Pelizaeus-Merzbacher) Mucopolysaccharidosis (Hunter syndrome, Hurler disease) Glycoprotein storage disorders (mucolipidosis, pseudoHurler) Mucolipidoses (ML type I-IV; sialidosis) |
a Considered a constitutional erythrocyte disorder; this group also includes hemoglobinopathies, membrane defects, and enzyme defects; for example, thalassemias, sickle cell disorders, hereditary spherocytosis, and pyruvate kinase deficiency (not discussed here). |
b Considered a constitutional granulocyte disorder; this group also includes Kostmann agranulocytosis syndrome, cyclic neutropenia, and Chediak-Higashi syndrome (see Table 24-5). |
c Considered a constitutional megakaryocytic disorder. |
ALD, adrenal leukodystrophy; MLD, metachromatic leukodystrophy. |