The Antioxidant, Anti-inflammatory, and Antiapoptotic Effects of Wolfberry in Fatty Liver Disease




Becker U, Gronbaek M, Johansen D, Sorensen TI. Lower risk for alcohol-induced cirrhosis in wine drinkers. Hepatology (Baltimore, Md). 2002;35(4):868–75. doi:10.1053/jhep.2002.32101.


Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the dionysos nutrition and liver study. Hepatology (Baltimore, Md). 2005;42(1):44–52. doi:10.1002/hep.20734.


Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, Saveria Croce L, Sasso F, Pozzato G, Cristianini G, Brandi G. Drinking habits as cofactors of risk for alcohol induced liver damage. The dionysos study group. Gut. 1997;41(6):845–50.PubMedCentralPubMed


Bellentani S, Pozzato G, Saccoccio G, Crovatto M, Croce LS, Mazzoran L, Masutti F, Cristianini G, Tiribelli C. Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study. Gut. 1999;44(6):874–880.PubMedCentralPubMed


Bouza C, Angeles M, Munoz A, Amate JM. Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review. Addiction (Abingdon, England). 2004;99(7):811–28. doi:10.1111/j.1360-0443.2004.00763.x.


Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology (Baltimore, Md). 2004;40(6):1387–95. doi:10.1002/hep.20466.


Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology (Baltimore, Md). 2005a;42 (5):987–1000. doi:10.1002/hep.20920.


Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, Baldi S, Ponti V, Pagano G, Ferrannini E, Rizzetto M. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia. 2005b;48(4):634–42. doi:10.1007/s00125-005-1682-x.


Caldwell SH, Harris DM, Patrie JT, Hespenheide EE. Is NASH underdiagnosed among African Americans? Am J Gastroenterol. 2002;97(6):1496–500. doi:10.1111/j.1572-0241.2002.05795.x.PubMed


Chao JC, Chiang SW, Wang CC, Tsai YH, Wu MS. Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells. World J Gastroenterol. 2006;12(28):4478–84.PubMedCentralPubMed


Cheng D, Kong H. The effect of Lycium barbarum polysaccharide on alcohol-induced oxidative stress in rats. Molecules (Basel, Switzerland). 2011;16(3):2542–50. doi:10.3390/molecules16032542.


Cho SH, Park EJ, Kim EO, Choi SW. Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller. Nutr Res Pract. 2011;5(5):412–20. doi:10.4162/nrp.2011.5.5.412.PubMedCentralPubMed


Corrao G, Ferrari P, Zambon A, Torchio P. Are the recent trends in liver cirrhosis mortality affected by the changes in alcohol consumption? Analysis of latency period in European countries. J Stud Alcohol. 1997;58(5):486–94.PubMed


Cui B, Liu S, Lin X, Wang J, Li S, Wang Q, Li S. Effects of Lycium barbarum aqueous and ethanol extracts on high-fat-diet induced oxidative stress in rat liver tissue. Molecules (Basel, Switzerland). 2011;16(11):9116–28. doi:10.3390/molecules16119116.


Czaja AJ, Freese DK. Diagnosis and treatment of autoimmune hepatitis. Hepatology (Baltimore, Md). 2002;36(2):479–97. doi:10.1053/jhep.2002.34944.


De Minicis S, Brenner DA. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J Gastroenterol Hepatol. 2008;23(Suppl 1):S98–103. doi:10.1111/j.1440-1746.2007.05277.x.PubMed


Diehl AM. Obesity and alcoholic liver disease. Alcohol. 2004;34(1):81–7. doi:http://​dx.​doi.​org/​10.​1016/​j.​alcohol.​2004.​07.​010.PubMed


Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Investig. 2005;115(5):1343–51. doi:10.1172/jci23621.PubMedCentralPubMed


Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol. 2009;50(1):204–10. doi:10.1016/j.jhep.2008.10.010.PubMed


Fan JG, Zhu J, Li XJ, Chen L, Li L, Dai F, Li F, Chen SY. Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol. 2005;43 (3):508–14. doi:10.1016/j.jhep.2005.02.042.PubMed


Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, Burgart LJ, Gores GJ. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology (Baltimore, Md). 2004;40(1):185–94. doi:10.1002/hep.20283.


Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL. Overweight and obesity in the United States: prevalence and trends, 1960–1994. Int J Obes Relat Metab Disord. 1998;22 (1):39–47.PubMed


Friedman SL, Arthur MJ. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Investig. 1989;84(6):1780–5. doi:10.1172/jci114362.PubMedCentralPubMed


Gabele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem. 2005;280(14):13374–82. doi:10.1074/jbc.M409444200.PubMed


Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011;141(5):1572–85. doi:10.1053/j.gastro.2011.09.002.PubMedCentralPubMed


Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biological Chem. 2002;277 (50):48115–21. doi:10.1074/jbc.M209459200.


Garbutt JC, West SL, Carey TS, Lohr KN, Crews FT. Pharmacological treatment of alcohol dependence: a review of the evidence. JAMA. 1999;281(14):1318–25.PubMed


Gill RQ, Sterling RK. Acute liver failure. J Clin Gastroenterol. 2001;33(3):191–8.PubMed


Greene MW, Ruhoff MS, Roth RA, Kim JA, Quon MJ, Krause JA. PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function. Biochem Biophys Res Commun. 2006;349(3):976–86. doi:10.1016/j.bbrc.2006.08.158.PubMed


Guilbert JJ.The world health report 2002—reducing risks, promoting healthy life. Educ Health (Abingdon). 2003;16(2):230.


Ha KT, Yoon SJ, Choi DY, Kim DW, Kim JK, Kim CH. Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. J Ethnopharmacol. 2005;96(3):529–35. doi:10.1016/j.jep.2004.09.054.PubMed


Halsted CH. Nutrition and alcoholic liver disease. Semin Liver Dis. 2004;24(3):289–304. doi:10.1055/s-2004-832941.PubMed


Hashimoto E, Yatsuji S, Tobari M, Taniai M, Torii N, Tokushige K, Shiratori K. Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. J Gastroenterol. 2009;44(Suppl 19):89–95. doi:10.1007/s00535-008-2262-x.PubMed


Hisatomi S, Kumashiro R, Sata M, Ishii K, Tanikawa K. Gender difference in alcoholic liver disease in Japan—an analysis based on histological findings. Hepatol Res. 1997;8(2):113–20. doi:http://​dx.​doi.​org/​10.​1016/​S1386-6346(97)00062-4.


Horton JD, San Miguel FL, Membreno F, Wright F, Paima J, Foster P, Ortiz JA. Budd-Chiari syndrome: illustrated review of current management. Liver Int. 2008;28(4):455–66. doi:10.1111/j.1478-3231.2008.01684.x.PubMed


Ioannou GN, Dominitz JA, Weiss NS, Heagerty PJ, Kowdley KV. The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology. 2004;126(5):1293–301.PubMed


Ishibashi H, Nakamura M, Komori A, Migita K, Shimoda S. Liver architecture, cell function, and disease. Semin Immunopathol. 2009;31(3):399–409. doi:10.1007/s00281-009-0155-6.PubMed


James PT, Rigby N, Leach R. The obesity epidemic, metabolic syndrome and future prevention strategies. Eur J Cardiovasc Prev Rehabil. 2004;11(1):3–8.PubMed


Kakizaki S, Takizawa D, Yamazaki Y, Nakajima Y, Ichikawa T, Sato K, Takagi H, Mori M, Kasama K. Nonalcoholic fatty liver disease in Japanese patients with severe obesity who received laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in comparison to non-Japanese patients. J Gastroenterol. 2008;43(1):86–92. doi:10.1007/s00535-007-2130-0.PubMed


Kamper-Jorgensen M, Gronbaek M, Tolstrup J, Becker U. Alcohol and cirrhosis: dose–response or threshold effect? J Hepatol 2004;41(1):25–30. doi:10.1016/j.jhep.2004.03.002.PubMed

Jun 28, 2017 | Posted by in PHARMACY | Comments Off on The Antioxidant, Anti-inflammatory, and Antiapoptotic Effects of Wolfberry in Fatty Liver Disease

Full access? Get Clinical Tree

Get Clinical Tree app for offline access