and Itch Pathways
Fig. 1 Lack of corresponding functionally defined C-fiber classes in primates and molecular markers in rodents. Only for the markers of Mas-related G-protein-coupled receptor B4 (MrgprB4) and vesicular glutamate transporter…
Modulation of Itch Transmission in the Spinal Cord
Fig. 1 Schematic representation of desirable sites of action of antipruritic agents. Since vigorous scratching worsens skin conditions, suppression of both itching and scratching is important in the treatment of…
of Pruriceptive Signals
Fig. 1 Structure of natriuretic peptides. A comparison of the primary structure (table) of mouse, human, and rat natriuretic polypeptides reveals that Nppa displays greater sequence conservation than Nppb. Despite…
Role of the Mrgpr Receptor Family in Itch
Fig. 1 Venn diagram summarizing the expression of Mrgprs in DRG neurons. The small- to medium-diameter neurons represent the major primary sensory neuron population in the DRG and can be…
Topical and Systemic Therapies for Itch
Agent Indications Major adverse effects Coolants: menthol, camphor, phenol Most pruritic conditions Skin irritation Capsaicin 0.025–0.1 % • Neuropathic itch • Prurigo nodularis • Aquagenic pruritus • Uremic pruritus Initial burning…
Antagonists and Itch
Cell/structure Effects of SP/NK1R Potential translational importance References Epidermal dendritic cells Increased migration to skin-draining lymph nodes; inhibition of IL-10 synthesis and secretion NK1R agonists: potential adjuvant for enhancing the…
of Cytokines and Chemokines in Itch
Fig. 1 IL-31 is predominantly produced by TH2 cells in humans. Factors influencing this release include exogenous triggers such as staphylococcal enterotoxin B (SEB), house dust mites (HDM) and endogenous…
Epidemiology and Quality of Life
Author N Population Age % Female 12-month cumulative incidence Point prevalence 12-month prevalence Lifetime prevalence Rea (1976) 1,979 Residents of North Lambeth with skin diseases 15–74 49.3 % N/A 8.2 % N/A…
Background of Itch
1922 Von Frey suggests that itch is transmitted by the same network of fibres as pain and may be induced by mechanical, thermal, chemical and thermal stimuli 1939 Bickford proposes…
