Quality and Managerial Issues

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Quality and Managerial Issues

Quality and Managerial Issues Introduction Clinical and laboratory services do not operate in isolation but are integrated into the clinical and managerial framework of a hospital, and in the UK…

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Tissue Typing

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Tissue Typing

Tissue Typing Introduction Key elements Key elements for successful transplantation are: ability to correctly identify tissue types of recipients and donors prediction of graft rejection (host versus graft) in the…

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Cellular Investigations

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Cellular Investigations

Cellular Investigations Introduction Cellular investigations include: identification of cell-surface phenotype identification of intracellular proteins identification of cellular function, including activation identification of secreted products (cytokines, chemokines) identification of abnormal cellular…

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Allergy Tests

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Allergy Tests

Allergy Tests Introduction The techniques used for allergy diagnosis in vitro are those already discussed in Chapters 17 and 18, and include RIA and EIA. Flow cytometry, as discussed in…

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Autoantibodies

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Autoantibodies

Autoantibodies Introduction There are many hundreds of reported autoantibodies, not all of clinical value. The repertoire of the typical regional immunology laboratory will cover most of those described below. Some…

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Immunochemistry

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Immunochemistry

Immunochemistry Techniques Electrophoresis, immunoelectrophoresis, immunofixation, isoelectric focusing, and immunoblotting Serum electrophoresis The most basic technique for the detection of serum proteins. Serum is applied to an electrolyte containing agarose gel…

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Immunotherapy

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Immunotherapy

Immunotherapy Introduction The aim of this chapter is to give an overview of the very complex but exciting area of immunotherapy. Despite great advances in the basic science, the results…

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Miscellaneous Conditions

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Miscellaneous Conditions

Miscellaneous Conditions Sarcoidosis Sarcoidosis is a multisystem disease characterized by non-caseating granulomata. Presentation Common presentations include: asymptomatic bihilar lymphadenopathy erythema nodosum, arthritis, and hilar lymphadenopathy (Löfgren’s syndrome) uveo-parotid fever (von…

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Transplantation

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Transplantation

Transplantation Stem cell transplantation (HSCT) 1: clinical indications and types of HSCT Clinical indications Severe combined immunodeficiency (SCID): all types (see Chapter 1). Combined immunodeficiency where there is reason to…

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Vasculitis

Jul 22, 2016 by in GENERAL SURGERY Comments Off on Vasculitis

Vasculitis Causes of vasculitis The term ‘vasculitis’ implies inflammation affecting predominantly the blood vessels. The effects of the process depend on the location of the inflammatory change and the size…

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