Registries and Directories of Clinical Trials, plus Disclosure of Their Results and Archiving Their Data In science the credit goes to the man who convinces the world, not the man…
Clinical Trials Come of Age My interest in science was always essentially limited to the study of principles … That I have published so little is due to this same…
Surrogate Endpoints and Biomarkers Science is facts. Just as houses are made of stones, so is science made of facts. But a pile of stones is not a house and…
Improving the Standards of Clinical Trial Publications Science is feasible when the variables are few and can be enumerated; when their combinations are distinct and clear. We are tending toward…
Human Subject Protection and Ethical Issues in Clinical Trials It is difficult to say what truth is, but sometimes so easy to recognize a falsehood. –Albert Einstein Whoever is careless…
Interactions between Clinicians and Statisticians for Analysis and Interpretation of Clinical Data The most difficult thing is not to fool yourself, because you are the easiest one to fool. –Richard…
Incorporating Benefit-to-risk Determinations in Drug Development An hour sitting with a pretty girl on a park bench passes like a minute, but a minute sitting on a hot stove seems…
Contract Research Organizations and Outsourcing Strategies Science is a system of statements based on direct experience, and controlled by experimental verification. Verification in science is not, however, of single statements…
Clinical Significance The years of searching in the dark for a truth that one feels but cannot express, the intense desire and the alternations of confidence and misgiving until one…
Conducting Clinical Trials Efficiently and Rapidly The art of medicine cannot be inherited, nor can it be copied from books. –Paracelsus The goal of conducting more clinical trials as efficiently…
