Pharmacology: Its role in drug discovery
Chapter 11 Pharmacology Its role in drug discovery H P. Rang Introduction Pharmacology as an academic discipline, loosely defined as the study of the effects of chemical substances on living…
Choosing the target
Chapter 6 Choosing the target H P. Rang, R G. Hill Introduction: the scope for new drug targets The word ‘target’ in the context of drug discovery has several common…
Clinical imaging in drug development
Chapter 18 Clinical imaging in drug development P M. Matthews Introduction Preclinical and clinical imaging has already made a significant contribution to drug development. Almost 30% of new molecular entities…
Assessing drug safety
Chapter 15 Assessing drug safety H P. Rang, R G. Hill Introduction Since the thalidomide disaster, ensuring that new medicines are safe when used therapeutically has been one of the…
Pharmaceutical development
Chapter 16 Pharmaceutical development T. Lundqvist, S. Bredenberg Introduction Active pharmaceutical ingredients (API) in pharmaceutical products must be formulated to dosage forms suitable for handling, distribution and adminstration to patients….
The drug discovery process: General principles and some case histories
Chapter 4 The drug discovery process General principles and some case histories H P. Rang, R G. Hill Introduction The creation of a new drug can be broadly divided into…
The development of the pharmaceutical industry
Chapter 1 The development of the pharmaceutical industry H P. Rang Antecedents and origins Our task in this book is to give an account of the principles underlying drug discovery…
Therapeutic modalities
Chapter 3 Therapeutic modalities H P. Rang, H. LeVine, R. Hill Introduction Therapeutics in its broadest sense covers all types of intervention aimed at alleviating the effects of disease. The…
Scaffolds: Small globular proteins as antibody substitutes
Chapter 13 Scaffolds Small globular proteins as antibody substitutes D. Grabulovski, J. Bertschinger Introduction An emerging field in pharmaceutical biotechnology is represented by the generation of novel binding molecules based…
Intellectual property in drug discovery and development
Chapter 19 Intellectual property in drug discovery and development P. Grubb As is clear from the rest of this book, it costs a great deal of effort and money to…
