Metastatic Carcinoma Key Facts Clinical Issues Cough, chest pain, dyspnea, hemoptysis, and pleural effusion are most common presenting symptoms Most common primary sites: Genital, gastrointestinal and genitourinary tracts, pancreatohepatobiliary tract,…
Overview of Malignant Pleural Neoplasms Cut section of the lung in a patient with malignant pleural mesothelioma shows a thick rind of whitish tumor tissue surrounding the outer surface of…
Wegener Granulomatosis Key Facts Etiology/Pathogenesis No definitive etiology is known for WG Clinical Issues Incidence More common in adults, usually in 5th decade of life Since WG is systemic and…
Extrinsic Allergic Alveolitis Key Facts Terminology Hypersensitivity pneumonitis (HP) Granulomatous lung disease secondary to inhalation of organic antigens or chemicals Etiology/Pathogenesis History of exposure to organic antigens Saccharopolyspora tectivirgula in…
Hard Metal Pneumoconiosis Pneumonitis Key Facts Terminology Type of pneumonitis caused by exposure to hard metal (cobalt) Etiology/Pathogenesis Exposure to hard metal Hard metal is combination of tungsten with cobalt…
Adenovirus Key Facts Clinical Issues Accounts for about 10% of all pneumonias in children and infants Epidemics have been reported in military personnel Microscopic Pathology 2 major patterns of lung…
Metastatic Malignant Melanoma Key Facts Clinical Issues Lung is frequent site of metastasis for malignant melanoma Middle-aged to elderly patients Image Findings Multiple, well-defined nodules in periphery of lungs Endobronchial…
Allergic Angiitis and Granulomatosis (Churg-Strauss) Key Facts Terminology Systemic process characterized by presence of vasculitis, blood eosinophilia, and asthma Etiology/Pathogenesis No definitive etiology has been defined for Churg-Strauss syndrome Probably…
Erdheim-Chester Disease Key Facts Terminology Rare histiocytic infiltrative disorder that most commonly affects bones but may affect other organs, including lung Clinical Issues Bone involvement is most common site 50%…
Langerhans Cell Histiocytosis Key Facts Terminology Proliferation of Langerhans cells that form multiple interstitial, bilateral, peribronchiolar pulmonary nodules Clinical Issues Highest incidence is in cigarette smokers (95% of patients) 18-40…
