Molecular Factors Index Molecular Factors Discussed Molecular Factor Chromosomal Location Definition/Alternative Names Chapters β-catenin 3p21 catenin (cadherin-associated protein), beta 1; beta-catenin; CTNNB1 Adrenal Cortical Adenoma; Adrenal Cortical Carcinoma; Calcifying Fibrous…
Antibody Index Antibodies Discussed Antibody Name/Symbol Antibody Description Clones/Alternative Names Chapters α-1-antichymotrypsin alpha 1 antichromotrypsin Calcifying Fibrous Tumor α-1-antitrypsin alpha 1 antitrypsin A1AT Yolk Sac Tumor α-fetoprotein alpha 1 fetoprotein…
Glioblastoma Alexandros D. Polydorides, MD, PhD Key Facts Terminology Highly malignant (grade IV) astrocytic neoplasm Etiology/Pathogenesis Secondary GBM: From lower grade astrocytoma In 4-5 years; women, children; TP53 mutation Primary…
Protocol for Brain/Spinal Cord Tumor Specimens Brain/Spinal Cord Biopsy/Resection *History of Previous Tumor/Familial Syndrome *____ None known *____ Known (specify, if known: ______________________________) *____ Not specified Specimen Type/Procedure ____ Open…
Oligodendroglioma Alexandros D. Polydorides, MD, PhD Key Facts Clinical Issues 2-5% of all primary brain tumors, 5-25% of gliomas Most occur in adults, 5-7% arise in infancy/childhood 90% in supratentorial…
Simple Bone Cyst Jessica M. Comstock, MD Key Facts Terminology Unicameral bone cyst Solitary bone cyst Benign, solitary cyst in metaphysis of long bones Clinical Issues 1st and 2nd decades…
Aneurysmal Bone Cyst Jessica M. Comstock, MD Key Facts Terminology Solitary expansile lesion, most commonly involving long bones or spine Clinical Issues 1st and 2nd decade of life Secondary reactive…
Inflammatory Myofibroblastic Tumor Karen S. Thompson, MD Key Facts Terminology Tumor of myofibroblastic spindle cells with inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils Intermediate biological potential: Propensity to recur,…
Inclusion Body Fibromatosis Elizabeth A. Montgomery, MD Key Facts Terminology Nodular proliferation of benign fibroblastic and myofibroblastic cells with characteristic intracytoplasmic eosinophilic spherical inclusions Clinical Issues Broad-based or dome-shaped, nontender…
Fibrodysplasia Ossificans Progressiva Angelica R. Putnam, MD Key Facts Terminology Rare disabling genetic disorder of progressive heterotopic ossification Etiology/Pathogenesis Heterozygous activating mutation of gene encoding activin receptor A type 1/activin-like…
