Well-differentiated Neuroendocrine Neoplasm, Pancreas Vikram Deshpande, MD Key Facts Etiology/Pathogenesis MEN1 von Hippel-Lindau syndrome Tuberous sclerosis Sporadic Clinical Issues Surgical resection remains mainstay of therapy for tumors confined to pancreas…
Solid-Pseudopapillary Tumors Grace E. Kim, MD Key Facts Terminology Solid-pseudopapillary tumor (SPT) Low-grade malignant neoplasm of uncertain cellular differentiation Etiology/Pathogenesis 90-100% harbor mutations in β-catenin gene Clinical Issues Occurs predominately…
Poorly Differentiated Neuroendocrine Carcinoma, Pancreas Vikram Deshpande, MD Key Facts Clinical Issues Very aggressive neoplasms Patients may benefit from platinum-based chemotherapy Microscopic Pathology Small cell variant Resembles small cell carcinomas…
Pancreatoblastoma Laura Webb Lamps, MD Key Facts Clinical Issues Rare overall but most common malignant pancreatic neoplasm of childhood 2/3 of PB occur in children, 1/3 in adults Mean age…
Intraductal Papillary Mucinous Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Grossly visible, mucin-producing epithelial neoplasm Predominantly grows within main duct &/or its branches Classified into main duct, combined, or branch…
Intraductal Tubulopapillary Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Solid epithelial neoplasm composed of back-to-back tubular glands and papillae that grows within and obstructs pancreatic ducts No grossly visible mucin…
Intraductal Oncocytic Papillary Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Grossly cystic neoplasm with intraductal growth pattern and oncocytic epithelium Clinical Issues Rare entity with ˜ 40 cases reported in…
Mucinous Cystic Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Neoplasm composed of mucin-producing epithelial cells associated with ovarian-type stroma Clinical Issues Comprises 10% of cystic lesions of pancreas Average age…
Acinar Cell Cystadenoma Vikram Deshpande, MD Key Facts Terminology Benign pancreatic cyst lined by acinar cells Clinical Issues Young to middle-aged Benign cyst without risk of malignant transformation Macroscopic Features…
Ductal Adenocarcinoma, including Variants Mari Mino-Kenudson, MD Key Facts Terminology Adenocarcinoma arising in pancreatic ductal system Comprises 85-90% of all pancreatic neoplasms Clinical Issues Most cases unresectable at presentation Nonspecific…
