Solid-Pseudopapillary Tumors Grace E. Kim, MD Key Facts Terminology Solid-pseudopapillary tumor (SPT) Low-grade malignant neoplasm of uncertain cellular differentiation Etiology/Pathogenesis 90-100% harbor mutations in β-catenin gene Clinical Issues Occurs predominately…
Well-differentiated Neuroendocrine Neoplasm, Pancreas Vikram Deshpande, MD Key Facts Etiology/Pathogenesis MEN1 von Hippel-Lindau syndrome Tuberous sclerosis Sporadic Clinical Issues Surgical resection remains mainstay of therapy for tumors confined to pancreas…
Poorly Differentiated Neuroendocrine Carcinoma, Pancreas Vikram Deshpande, MD Key Facts Clinical Issues Very aggressive neoplasms Patients may benefit from platinum-based chemotherapy Microscopic Pathology Small cell variant Resembles small cell carcinomas…
Pancreatoblastoma Laura Webb Lamps, MD Key Facts Clinical Issues Rare overall but most common malignant pancreatic neoplasm of childhood 2/3 of PB occur in children, 1/3 in adults Mean age…
Intraductal Papillary Mucinous Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Grossly visible, mucin-producing epithelial neoplasm Predominantly grows within main duct &/or its branches Classified into main duct, combined, or branch…
Intraductal Tubulopapillary Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Solid epithelial neoplasm composed of back-to-back tubular glands and papillae that grows within and obstructs pancreatic ducts No grossly visible mucin…
Intraductal Oncocytic Papillary Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Grossly cystic neoplasm with intraductal growth pattern and oncocytic epithelium Clinical Issues Rare entity with ˜ 40 cases reported in…
Mucinous Cystic Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Neoplasm composed of mucin-producing epithelial cells associated with ovarian-type stroma Clinical Issues Comprises 10% of cystic lesions of pancreas Average age…
Acinar Cell Cystadenoma Vikram Deshpande, MD Key Facts Terminology Benign pancreatic cyst lined by acinar cells Clinical Issues Young to middle-aged Benign cyst without risk of malignant transformation Macroscopic Features…
Ductal Adenocarcinoma, including Variants Mari Mino-Kenudson, MD Key Facts Terminology Adenocarcinoma arising in pancreatic ductal system Comprises 85-90% of all pancreatic neoplasms Clinical Issues Most cases unresectable at presentation Nonspecific…
