Hemangiomas
Hemangiomas Key Facts Clinical Issues Benign vascular lesions that occur in breast parenchyma and skin May be detected as palpable masses, circumscribed masses on imaging, or incidental findings Recurrence even…
Lobular Carcinoma In Situ
Lobular Carcinoma In Situ Key Facts Terminology Lobular carcinoma in situ (LCIS) Etiology/Pathogenesis Hallmark molecular feature of in situ and invasive lobular carcinoma is loss of cellular cohesion Loss of…
Implant Pathology
Implant Pathology Key Facts Terminology Breasts may be augmented or replaced by foreign material for cosmetic reasons or for reconstruction after surgery Foreign material (such as silicone, paraffin, or organic…
Expression Profiling, Protein
Expression Profiling, Protein This grade 3 invasive carcinoma has a high mitotic rate . Additional information is provided by the use of IHC markers to determine prognosis and guide selection…
Invasive Micropapillary Carcinoma
Invasive Micropapillary Carcinoma Key Facts Terminology Invasive micropapillary carcinoma (IMPC) Special histologic subtype of infiltrating ductal carcinoma Clinical Issues Increased incidence of lymph node metastases and local recurrence 40-50% of…
Granulomatous Lobular Mastitis
Granulomatous Lobular Mastitis Key Facts Terminology Specific disease of breast occurring only in parous women and characterized by lobulocentric granulomas Etiology/Pathogenesis Association with prior childbirth suggests cell-mediated response to antigen…
Fat Necrosis
Fat Necrosis Key Facts Terminology Common benign inflammatory reaction secondary to injury of breast adipose tissue Wide spectrum of clinical and radiologic appearances May be confused with carcinoma, both clinically…
Collagenous Spherulosis
Collagenous Spherulosis Key Facts Terminology Collagenous (mucinous) spherulosis (CS) Incidental microscopic finding in 1-2% of biopsies that contain hyperplastic ductal lesions Important to recognize CS because lesion may superficially resemble…
Nodular Fasciitis
Nodular Fasciitis Key Facts Terminology Benign self-limited proliferation of fibroblasts and myofibroblasts Clinical Issues Presents as rapidly growing painful or tender mass Without treatment, tumors will spontaneously regress within a…
Angiosarcoma
Angiosarcoma Key Facts Terminology Malignant neoplasm arising from endothelial cells or their precursors Etiology/Pathogenesis Breast is most common site of origin of angiosarcomas; however, they comprise < 0.1% of breast…
