The impact of diagnostic immunohistochemistry (IHC) for the surgical pathologist is legendary, and it is best appreciated when studying malignancies of unknown primary site. A cost-effective tool, IHC is performed…
Overview Melanoma continues to represent one of the greatest diagnostic challenges in surgical pathology and is an important source of litigation. Both as a primary lesion in the skin and…
During the last 2 decades, the approach to histopathologic diagnosis has been dramatically transformed by immunohistochemistry (IHC), specifically in the diagnosis and classification of tumors, and more recently in the…
Overview The hematologic system comprises a variety of different tissue and cell types. These include a diverse range of cell functions and organs, including the bone marrow, spleen, and lymph…
Overview Immunohistochemistry (IHC), or immunocytochemistry (ICC), is a laboratory technique used to detect specific antigens (i.e., proteins) in tissues or cells based on antigen-antibody recognition; it seeks to exploit the…
Overview Tumors of soft tissue and bone are a diverse family, and categorization continues to evolve as more insight is gained into their patterns of differentiation and the underlying molecular…
General Principles of Molecular Biology Immunohistochemistry (IHC) is a common technique used for the detection of protein expression in various tissue samples. In modern pathology practice, this methodology is expanded…
