Drug safety, toxicology and pharmacovigilance
A drug has to be demonstrated to be reasonably safe and effective before it can enter the clinic (see Chapter 10 ). An integrated risk assessment will be made on…
Regulation of drug use
Drug regulation seeks to ensure the quality of the whole process of making and using a new medicine. Thus there are strict regulatory requirements to adhere to on the synthesis,…
Pharmacodynamics and the measurement of drug action
The action of drugs is usually measured by bioassay, which is the measurement of potency or activity of a drug using a biological response, using the principles of drug action…
Drug discovery and the development of small molecules
Drug discovery has evolved in the last 50–60 years from a purely phenotypic screening approach (compound libraries subjected to systems-based assays to identify compounds with biological effects) towards a target-based…
Pharmacology, drug names and classification systems
Pharmacology is derived from the ancient Greek word for a drug, pharmakon, and is the study of how drugs and xenobiotics affect body function and also how the body will…
