Chronic Granulomatous Disease Megan K. Dishop Chronic granulomatous disease (CGD) is an inherited form of primary immunodeficiency caused by impaired phagocyte NADPH oxidase activity, resulting in deficient superoxide production and…
Metastatic Lung Tumors in Children and Adolescents Megan K. Dishop Metastatic tumors are the most common tumors of the lung in childhood. The most common metastatic solid tumors in routine…
Other Primary Lung Tumors in Children Megan K. Dishop Mass lesions of the lung in children are most commonly developmental malformations or cystic lesions, with a ratio of 10 non-neoplastic…
Pleuropulmonary Blastoma Megan K. Dishop Claire Langston Pleuropulmonary blastoma, a relatively recently recognized childhood malignancy, is an embryonal tumor of the lung, pleura, or mediastinum derived from the thoracic splanchnopleural…
Pulmonary Hypoplasia Megan K. Dishop Pulmonary hypoplasia is a decrease in weight and/or volume of the lung due to impaired growth in utero. It is identified in approximately 14% of…
Acinar Dysplasia Megan K. Dishop Claire Langston This condition is an exceedingly rare but quite striking form of primary pulmonary hypoplasia with arrest of lung development at an immature stage…
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins Megan K. Dishop Claire Langston Alveolar capillary dysplasia with misalignment of pulmonary veins is an increasingly recognized cause of persistent pulmonary hypertension…
Genetic Disorders of Surfactant Metabolism (SFTPB, SFTPC, and ABCA3 Mutations) Megan K. Dishop The genetic disorders of surfactant metabolism are a group of diseases caused by mutations in genes affecting…
Primary Ciliary Dyskinesia Megan K. Dishop Primary ciliary dyskinesia (PCD) is a disorder of immotile or abnormally motile cilia resulting in symptoms of chronic recurrent respiratory infection, sinusitis, and otitis…
Cystic Fibrosis Megan K. Dishop Claire Langston Cystic fibrosis is the major cause of severe chronic lung disease in children. It also is the principal reason for lung transplantation in…
