Basicmedical Key

Lamotrigine David Ficker MECHANISM OF ACTION Blocks voltage-activated Na channels Blocks release of glutamate and aspartate during repetitive firing Inhibits high-amplitude calcium currents EFFICACY Epilepsy—Monotherapy Trials Study Type. Randomized controlled…

Gabapentin Jennifer Cavitt MECHANISM Binds to α-2-δ subunit of voltage-gated calcium channels in the neuron Reduces depolarization-dependent calcium influx, modulating excitatory neurotransmitter release Gabapentin structurally similar to neurotransmitter γ-aminobutyric acid…

Felbamate Michael Privitera (Editor’s Note: The use of felbamate is associated with a marked increase in the incidence of aplastic anemia, and clinicians should carefully assess its risks and benefits.)…

Carbamazepine Timothy Welty MECHANISM OF ACTION Blocks voltage-activated Na channels Reduces polysynaptic responses Blocks post-tetanic potentiation Depresses thalamic potentials Depresses bulbar and polysynaptic reflexes EFFICACY Epilepsy—Monotherapy in New-Onset Epilepsy Randomized…

Introduction and Instructions for Using Clinician’s Guide to Antiepileptic Drug Use Michael Privitera Antiepileptic Drugs in Epilepsy Treatment Antiepileptic treatments have a rich history, beginning in the ancient times and…