Fig. 2.1 Critical residues involved in TRPV1 function. TRPV1 topology highlighting residues implicated in the activation, sensitisation, desensitisation, gating properties or permeation of the channel 2.6.1 The N Terminus Like other…
Fig. 6.1 Outlines the hypothetical mechanisms of AR, NAR, or MR and the role of capsaicin in TRPV1 desensitization in such clinical conditions. Stimulation of maxillary division of trigeminal nerves (V2)…
Fig. 5.1 Potential for TRPV1 modulation to reduce pain related to opioid-induced hyperalgesia. Either capsaicin-based defunctionalization or outright TRPV1 antagonism may be useful in alleviating this subset of chronic pain Further…
