Fig. 9.1 Inhibition of gastric acid basal output (BAO) by capsaicin in 16 healthy human subjects. (After Mózsik et al. 2005) 9.3.2 Affinity and Intrinsic Affinity Curves for the Capsaicin, Muscarinic…
Fig. 10.1 Schematic view of the CGRP receptor that consists of calcitonin receptor-like peptide (CLR), receptor activity modifying protein 1 (RAMP1), and receptor component protein (RCP) The human C-terminal fragment of…
Fig. 8.1 Structure of capsaicin. Capsaicin has three main moieties: vannillyl (methylcatechol group), amide bond, and an alkyl side chain Capsaicin is absorbed very rapidly by a nonactive process from the…
Fig. 1.1 Chemical structure of some exogenous and endogenous agonists of the transient receptor potential vanilloid type-1 (TRPV1) capsaicin receptor The first paper on studying the pharmacological effects of capsaicin was…
Study, duration n Age (years) Sex (M:F) OA site Formulation Outcomes Rate of application site burning Deal 1991 (Deal et al. 1991) 4 weeks 70 61 25M:45F Knee 0.025 % capsaicin VAS…
Fig. 3.1 Schematic Representation of TRPV1 LTD. a Presynaptic TRPV1 LTD, while mediated at the presynaptic terminal depressing glutamate neurotransmitter release, requires formation of postsynaptic 12-HPETE in order to activate TRPV1….
Peripheral neuropathic conditions treated with Topical capsaicin Postherpetic neuralgia (PHN) Painful diabetic polyneuropathy (PDPN) HIV-associated distal symmetrical polyneuropathy (HIV-DSPN) Persistent postsurgical pain 4.2 Neuropathic Pain Whether noted by clinician or…
Route Treatment Proposed mechanism of action Observation Spontaneous voiding – Oral Antimuscarinics Suppresses detrusor muscle contractions Tricyclic antidepressant Central and peripheral anticholinergic Catheterization Intermittent Drainage of bladder/urinary tract Condom (male)…
Dermatologic condition Clinical manifestations Post-herpetic neuralgia Pain persisting more than 90 days following the occurrence of herpes zoster infection Notalgia paresthetica Focal pruritus typically located unilaterally on the mid- or upper…
Omar M. E. Abdel-Salam (ed.)Progress in Drug ResearchCapsaicin as a Therapeutic Molecule201410.1007/978-3-0348-0828-6_7 © Springer Basel 2014 7. Capsaicin as an Anti-Obesity Drug Felix W. Leung1, 2, 3 (1) 111G, Division of Gastroenterology, Sepulveda Ambulatory Care Center,…
